Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| TK4018 | TK4018 | Denmark | 2000 | HIV1 | D | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | 3TC+ AZT+ SQV | 65 |
| 2 | 3TC+ AZT+ IDV | 8 |
| 3 | 3TC+ IDV+ D4T | 9 |
| 4 | None | 58 |
| 5 | 3TC+ D4T+ IDV | 30 |
| 6 | NFV+ 3TC+ D4T | 63 |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| D30DN, I54IV | K20KR, E35D, M36I, N37E, R41K, Q61HN, I62IV, L63LP, I64V, C67Y, H69Y |
| >TK4018| codons 1-99 PQITLWQRPLVTIKIGGQLREALLDTGADNTVLEDIELPGKWKPKMIGGIGGFVKVRQYD HVPVEIYGYKAIGTVLVGPTPVNIIGRNLLTQIGCTLNF |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| D67N, K70R, M184V | T215TS, K219Q | V35I, I47L, V60I, T69TA, K103R, D121H, K122E, I135T, D177E, T200I, Q207E, R211K, V245K, D250DE, S251I, A272S, L282C, T286A, I293V |
| >TK4018| codons 1-314 PISPIETVPVKLKPGMDGPKVKQWPLTEEKIKALIEICTEMEKEGKLSKIGPENPYNTPI FAIKKKNSARWRKLVDFRELNKRTQDFWEVQLGIPHPAGLKKRKSVTVLDVGDAYFSVPL HEDFRKYTAFTIPSTNNETPGIRYQYNVLPQGWKGSPAIFQSSMTKILEPFRKQNPEIVI YQYVDDLYVGSDLEIGQHRIKIEELREHLLKWGFSTPDQKHQKEPPFLWMGYELHPDKWT VQPIKLPEKEIWTVNDIQKLVGKLNWASQIYSGIKVKQLCKCLRGAKALTEVVPLTEEAE LELAENREILKEPV |
References
| Author | Title | Citation |
| Non-B Workgroup | Impact of HIV-1 subtype and antiretroviral therapy on protease and reverse transcriptase genotype: Results of a global collaboration. | PLoS Med, 2005 |