Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| TK4015 | TK4016a | Denmark | 2004 | HIV1 | D | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | 3TC+ AZT+ EFV | 42 |
| 2 | 3TC+ AZT+ TDF + NFV | 31 |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| M184V, L210W | T215C | K103N | I31R, V35I, K49R, V60I, K101Q, K122E, D123S, I135L, D177E, I178M, T200A, Q207E, V245K, D250E, A272P, L282C, L283I, T286A, I293V, D324E, Q334R |
| >TK4016a| codons 1-334 PISPIETVPVKLKPGMDGPKVKQWPLTEEKRKALIEICTEMEKEGKISRIGPENPYNTPI FAIKKKDSTKWRKLVDFRELNKRTQDFWEVQLGIPHPAGLQKNKSVTVLDVGDAYFSVPL DESFRKYTAFTIPSLNNETPGIRYQYNVLPQGWKGSPAIFQSSMTKILEPFRKQNPEMVI YQYVDDLYVGSDLEIGQHRAKIEELREHLWRWGFCTPDKKHQKEPPFLWMGYELHPDKWT VQPIKLPEKESWTVNDIQKLVGKLNWASQIYPGIKVKQLCKCIRGAKALTEVVPLTEEAE LELAENREILKEPVHGVYYDPSKELIAEIQKQGR |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| G73S, L89V | T12E, K14R, I15V, L19I, R41K |
| >TK4016a| codons 1-99 PQITLWQRPLVEIRVGGQIKEALLDTGADDTVLEEMNLPGKWKPKMIGGIGGFIKVRQYD QILIEICGHKAISTVLVGPTPVNIIGRNVLTQIGCTLNF |
References
| Author | Title | Citation |
| Non-B Workgroup | Impact of HIV-1 subtype and antiretroviral therapy on protease and reverse transcriptase genotype: Results of a global collaboration. | PLoS Med, 2005 |