Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| TK4014 | TK4014 | Denmark | 2003 | HIV1 | D | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | 3TC+ AZT+ RTV+ SQV | 29 |
| 2 | 3TC+ AZT+ NFV | 69 |
| 3 | ABC+3TC+AZT | 103 |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| T12TP, I13V, I15IV, K20R, M36MI, R41K, L63H, I64V, I72IV, V77I |
| >TK4014| codons 1-99 PQITLWQRPLVPVKVGGQLREALLDTGADDTVLEEINLPGKWKPKMIGGIGGFIKVRQYD QIHVEICGHKAVGTVLIGPTPVNIIGRNLLTQIGCTLNF |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| M41L, D67N, M184V, L210W, T215Y | V35T, E44D, K49R, V60I, T69S, K122E, D123S, I135KR, S162X, D177E, I178M, V179VI, T200I, Q207E, R211RK, V245EK, D250E, A272P, K277R, L282C, L283I, A288AT, I293V, E297K |
| >TK4014| codons 1-334 PISPIETVPVKLKPGMDGPKVKQWPLTEEKIKALTEICTELEKDGKISRIGPENPYNTPI FAIKKKNSSKWRKLVDFRELNKRTQDFWEVQLGIPHPAGLKKKKSVTVLDVGDAYFSVPL DESFRKYTAFTIPSKNNETPGIRYQYNVLPQGWKGSPAIFQXSMTKILEPFRKQNPEMII YQYVDDLYVGSDLEIGQHRIKIEELREHLWKWGFYTPDKKHQKEPPFLWMGYELHPDKWT VQPIELPEKESWTVNDIQKLVGKLNWASQIYPGIKVRQLCKCIRGTKTLTEVVPLTKEAE LELAENREILKEPVHGVYYDPSKDLIAEIQKQGQ |
References
| Author | Title | Citation |
| Non-B Workgroup | Impact of HIV-1 subtype and antiretroviral therapy on protease and reverse transcriptase genotype: Results of a global collaboration. | PLoS Med, 2005 |