Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| TK4012 | TK4012 | Denmark | 2003 | HIV1 | A | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | ABC+ D4T+ DDI | 27 |
| 2 | 3TC+ AZT+ EFV | 5 |
| 3 | ABC+ D4T+ DDI | 49 |
| 4 | ABC+ DDI+ 3TC+ AZT | 2 |
| 5 | 3TC+ AZT+ RTV+ SQV+ ABC | 4 |
| 6 | 3TC+ AZT+ ABC+ DDI | 8 |
| 7 | 3TC+ AZT+ ABC+ DDI | 1 |
| 8 | 3TC+ AZT+ ABC | 130 |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| M184V | K11T, V21VI, V35T, V60I, D121H, K122E, D123S, I135T, K173S, Q174K, D177E, V179I, T200A, Q207A, R211S, F214FL, V241VI, D250E, K281R, L283I, T286A, E291D, V292I, I293V, P294T, I326T |
| >TK4012| codons 1-333 PISPIETVPVTLKPGMDGPKIKQWPLTEEKIKALTEICTEMEKEGKISKIGPENPYNTPI FAIKKKDSTKWRKLVDFRELNKRTQDFWEVQLGIPHPAGLKKKKSVTVLDVGDAYFSVPL HESFRKYTAFTIPSTNNETPGIRYQYNVLPQGWKGSPAIFQSSMTKILEPFRSKNPEIII YQYVDDLYVGSDLEIGQHRAKIEELRAHLLSWGLTTPDKKHQKEPPFLWMGYELHPDKWT IQPIVLPEKESWTVNDIQKLVGKLNWASQIYAGIKVKQLCRLIRGAKALTDIVTLTEEAE LELAENREILKEPVHGVYYDPSKDLTAEIQKQG |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| K14R, E35D, M36I, N37D, R41K, R57K, H69K, L89M |
| >TK4012| codons 1-99 PQITLWQRPLVTIRIGGQLKEALLDTGADDTVLEDIDLPGKWKPKMIGGIGGFIKVKQYD QILIEICGKKAIGTVLVGPTPVNIIGRNMLTQIGCTLNF |
References
| Author | Title | Citation |
| Non-B Workgroup | Impact of HIV-1 subtype and antiretroviral therapy on protease and reverse transcriptase genotype: Results of a global collaboration. | PLoS Med, 2005 |