Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| TK4011 | TK4011 | Denmark | 2002 | HIV1 | C | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | AZT+ DDC+ SQV | 27 |
| 2 | 3TC+ D4T+ RTV | 96 |
| 3 | ABC+ DDI+ NFV | 34 |
| 4 | ABC+ DDI+ EFV+ IDV+ RTV | 59 |
| 5 | None | 28 |
| 6 | ABC+ DDI+ EFV+ IDV+ RTV | 45 |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| V82A, L90M | Q58E, G73S | L10V, T12S, I15V, L19I, K20R, M36I, L63P, H69K, A71V, I72L, I93L |
| >TK4011| codons 1-99 PQITLWQRPVVSIKVGGQIREALLDTGADDTVLEEINLPGRWKPKMIGGIGGFIKVREYD QIPIEICGKKVLSTVLVGPTPANIIGRNLMTQLGCTLNF |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| M41L, D67N, K70R, L74I, M184V, T215Y | A62V, K219E | V106M, G190A | P4S, T7P, V35T, E36A, T39D, E44D, K122E, D123E, S162Y, K173T, Q174K, N175Y, D177E, V179I, T200A, E203D, Q207E, H208Y, R211K, W212R, H221Y, L228H, V245Q, D250E, A272P, E291D, V292I, E297K |
| >TK4011| codons 1-324 PISSIEPVPVKLKPGMDGPKVKQWPLTEEKIKALTAICDELEKDGKISKIGPENPYNTPV FVIKKKNSTRWRKIVDFRELNKRTQDFWEVQLGIPHPAGLKKKKSMTVLDVGDAYFSVPL DEEFRKYTAFTIPSINNETPGIRYQYNVLPQGWKGSPAIFQYSMTKILEPFRTKYPEIII YQYVDDLYVASDLEIGQHRAKIDELREYLLKRGFYTPDEKYQKEPPFHWMGYELHPDKWT VQPIQLPEKESWTVNDIQKLVGKLNWASQIYPGIKVKQLCKLLRGTKALTDIIPLTKEAE LELAENREILKEPVHGVYYDPSKD |
References
| Author | Title | Citation |
| Non-B Workgroup | Impact of HIV-1 subtype and antiretroviral therapy on protease and reverse transcriptase genotype: Results of a global collaboration. | PLoS Med, 2005 |