Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| TK4010 | TK4010 | Denmark | 2000 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | 3TC+ D4T | 5 |
| 2 | 3TC+ AZT | 10 |
| 3 | 3TC+ AZT+ RTV+ SQV | 4 |
| 4 | None | 106 |
| 5 | 3TC+ AZT+ NFV | 9 |
| 6 | None | 3 |
| 7 | 3TC+ D4T+ NFV | 41 |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| L90M | I13V, I15V, K20T, E35D, M36I, R41K, R57K, L63P, H69K, V77I, L89M |
| >TK4010| codons 1-99 PQITLWQRPLVTVKVGGQLTEALLDTGADDTVLEDINLPGKWKPKMIGGIGGFIKVKQYD QIPIEICGKKAIGTVLIGPTPVNIIGRNMMTQIGCTLNF |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| M184V | V35T, K49R, V60I, K122E, D123N, I135T, E169D, Q174K, D177E, I178M, T200I, Q207E, R211K, I244V, V245Q, E248DN, A272P, K277R, L282C, P294ST | G152GV, V317Y |
| >TK4010| codons 1-324 PISPIETVPVKLKPGMDGPKVKQWPLTEEKIKALTEICTEMEKEGKISRIGPENPYNTPI FAIKKKDSTKWRKLVDFRELNKRTQDFWEVQLGIPHPAGLKKKKSVTVLDVGDAYFSVPL DENFRKYTAFTIPSTNNETPGIRYQYNVLPQVWKGSPAIFQSSMTKILDPFRKKNPEMVI YQYVDDLYVGSDLEIGQHRIKIEELREHLLKWGFTTPDKKHQKEPPFLWMGYELHPDKWT VQPVQLPDKDSWTVNDIQKLVGKLNWASQIYPGIKVRQLCKCLRGTKALTEVISLTEEAE LELAENREILKEPVHGYYYDPSKD |
References
| Author | Title | Citation |
| Non-B Workgroup | Impact of HIV-1 subtype and antiretroviral therapy on protease and reverse transcriptase genotype: Results of a global collaboration. | PLoS Med, 2005 |