Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| TK4007 | TK4007 | Denmark | 2002 | HIV1 | A | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | 3TC+ AZT+ NFV | 14 |
| 2 | 3TC+ NFV+ D4T | 7 |
| 3 | 3TC+ NFV+ AZT | 157 |
| 4 | 3TC+ AZT+ EFV | 12 |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| M184V | K103N | K238KT | V21VI, V35T, I50V, V118I, K122E, D123NS, I135T, I142V, K173S, Q174K, D177E, V179I, T200A, Q207A, R211S, F214L, V245Q, V261I, A272T, K281R, L283I, I293V, P294T, E312D | K277KE |
| >TK4007| codons 1-324 PISPIETVPVKLKPGMDGPKIKQWPLTEEKIKALTEICTEMEKEGKISKVGPENPYNTPV FAIKKKDSTKWRKLVDFRELNKRTQDFWEVQLGIPHPAGLKKNKSVTVLDVGDAYFSIPL DENFRKYTAFTIPSTNNETPGVRYQYNVLPQGWKGSPAIFQSSMTKILEPFRSKNPEIII YQYVDDLYVGSDLEIGQHRAKIEELRAHLLSWGLTTPDKKHQKEPPFLWMGYELHPDTWT VQPIQLPEKDSWTVNDIQKLIGKLNWASQIYTGIKVEQLCRLIRGTKALTEVVTLTEEAE LELAENREILKDPVHGVYYDPSKD |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| M46I | I13V, E35D, M36I, R41K, R57K, L63P, H69K, A71AV, L89T |
| >TK4007| codons 1-99 PQITLWQRPLVTVKIGGQLKEALLDTGADDTVLEDINLPGKWKPKIIGGIGGFIKVKQYD QIPIEICGKKVIGTVLVGPTPVNIIGRNTLTQIGCTLNF |
References
| Author | Title | Citation |
| Non-B Workgroup | Impact of HIV-1 subtype and antiretroviral therapy on protease and reverse transcriptase genotype: Results of a global collaboration. | PLoS Med, 2005 |