Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| TK4004 | TK4004 | Denmark | 2002 | HIV1 | C | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | 3TC+ AZT+ IDV | 164 |
| 2 | ABC+ D4T+ NVP+ RTV+ SQV | 50 |
| 3 | ABC+ D4T+ NVP+ NFV | 35 |
| 4 | ABC+ D4T+ NVP+ LPV | 1 |
| 5 | None | 15 |
| 6 | ABC+ D4T+ NFV | 28 |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| M41ML, D67N, T69D, K70R, T215Y | K219E | Y181C | A98G | V35T, E36A, T39E, S48T, V60I, D121Y, K122E, S163SI, K173T, D177E, V179I, T200A, Q207E, L228R, V245Q, E291D, V292I, I293V |
| >TK4004| codons 1-324 PISPIETVPVKLKPGMDGPKVKQWPLTEEKIKALTAICEELEKEGKITKIGPENPYNTPI FAIKKKNSDRWRKLVDFRELNKRTQDFWEVQLGIPHPGGLKKKKSVTVLDVGDAYFSVPL YEDFRKYTAFTIPSINNETPGIRYQYNVLPQGWKGSPAIFQSIMTKILEPFRTQNPEIII CQYMDDLYVGSDLEIGQHRAKIEELREHLLRWGFYTPDEKHQKEPPFRWMGYELHPDKWT VQPIQLPEKDSWTVNDIQKLVGKLNWASQIYAGIKVKQLCKLLRGTKALTDIVPLTEEAE LELAENREILKEPVHGVYYDPSKD |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| M46I, L90M | L10R, I15V, L19I, K20M, M36I, R41K, L63P, H69K, K70R, L89M, I93L |
| >TK4004| codons 1-99 PQITLWQRPRVTIKVGGQIMEALLDTGADDTVLEEINLPGKWKPKIIGGIGGFIKVRQYD QIPIEICGKRAIGTVLVGPTPVNIIGRNMMTQLGCTLNF |
References
| Author | Title | Citation |
| Non-B Workgroup | Impact of HIV-1 subtype and antiretroviral therapy on protease and reverse transcriptase genotype: Results of a global collaboration. | PLoS Med, 2005 |