Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| TK4003 | TK4003 | Denmark | 2000 | HIV1 | A | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | 3TC+ AZT+ NFV | 116 |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| N83D | L10V, I13V, K14R, G16E, E35D, M36I, R41K, K45R, R57K, L63T, H69K, K70R, L89M, I93L |
| >TK4003| codons 1-99 PQITLWQRPVVTVRIEGQLKEALLDTGADDTVLEDINLPGKWKPRMIGGIGGFIKVKQYD QITIEICGKRAIGTVLVGPTPVDIIGRNMLTQLGCTLNF |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| M184V | V35T, K122E, D123N, I135IV, I142V, K173S, Q174K, D177E, V179I, T200A, Q207A, R211S, F214L, V245Q, D250E, S251D, K275Q, T286A, E291D, V292I, I293V, E312D |
| >TK4003| codons 1-324 PISPIETVPVKLKPGMDGPKVKQWPLTEEKIKALTEICTEMEKEGKISKIGPENPYNTPV FAIKKKDSTKWRKLVDFRELNKRTQDFWEVQLGIPHPAGLKKKKSVTVLDVGDAYFSVPL DENFRKYTAFTIPSVNNETPGVRYQYNVLPQGWKGSPAIFQSSMTKILEPFRSKNPEIII YQYVDDLYVGSDLEIGQHRAKIEELRAHLLSWGLTTPDKKHQKEPPFLWMGYELHPDKWT VQPIQLPEKEDWTVNDIQKLVGKLNWASQIYAGIQVKQLCKLLRGAKALTDIVPLTEEAE LELAENREILKDPVHGVYYDPSKD |
References
| Author | Title | Citation |
| Non-B Workgroup | Impact of HIV-1 subtype and antiretroviral therapy on protease and reverse transcriptase genotype: Results of a global collaboration. | PLoS Med, 2005 |