<!--#if expr="$title" --> <!--#echo var="title" --> <!--#else --> HIV Drug Resistance Database <!--#endif -->
Stanford University HIV Drug Resistance Database - A curated public database designed to represent, store, and analyze the divergent forms of data underlying HIV drug resistance.

Isolate Data

Patient Isolate Region Year Species Subtype Source Clone Method
TK4001 TK4001 Denmark 2001 HIV1 C Plasma None

Treatment History
Order Regimen Weeks
1 3TC+ AZT+ NFV 2
2 3TC+ AZT+ NVP 64

RT Sequence
NRTIMajorDRMs NRTIMinorDRMs NNRTIMajorDRMs NNRTIMinorDRMs Polys UnusualMuts
M184V   K101E, G190A   V35T, T39E, S48T, K104R, K122E, D123N, I135IT, K173A, D177E, Q197K, T200A, Q207E, V245Q, A272P, K277R, E291D, V292I, I293V, K311KR, V314X, V317VA  
>TK4001| codons 34-324
LTEICEEMEKEGKITKIGPENPYNTPVFAIKKKDSTKWRKLVDFRELNKRTQDFWEVQLG
IPHPAGLEKKRSVTVLDVGDAYFSVPLDENFRKYTAFTIPSTNNETPGIRYQYNVLPQGW
KGSPAIFQSSMTKILEPFRAQNPEIVIYQYVDDLYVASDLEIGKHRAKIEELREHLLRWG
FTTPDKKHQKEPPFLWMGYELHPDKWTVQPIQLPEKDSWTVNDIQKLVGKLNWASQIYPG
IKVRQLCKLLRGTKALTDIVPLTEEAELELAENREILREPXHGAYYDPSKD

Protease Sequence
PIMajorDRMs PIMinorDRMs Polys UnusualMuts
    T12S, I15V, L19T, M36I, R41K, Q61E, L63P, H69K, V82I, L89M, I93L  
>TK4001| codons 1-99
PQITLWQRPLVSIKVGGQTKEALLDTGADDTVLEEINLPGKWKPKMIGGIGGFIKVRQYD
EIPIEICGKKAIGTVLVGPTPINIIGRNMLTQLGCTLNF

References
Author Title Citation
Non-B Workgroup Impact of HIV-1 subtype and antiretroviral therapy on protease and reverse transcriptase genotype: Results of a global collaboration. PLoS Med, 2005