Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| TK3035 | TK3035 | Denmark | 2000 | HIV1 | C | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | AZT+ IDV | 39 |
| 2 | AZT+ IDV+ 3TC | 65 |
| 3 | D4T+ DDI+ NFV+ NVP | 27 |
| 4 | D4T+ DDI+ NFV | 34 |
| 5 | None | 4 |
| 6 | ABC+ DDI+ EFV+ IDV+ RTV | 37 |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| M41L, D67N, K70R, L74I, L210W, T215Y | K219E | K101E, G190A | K238T | V35T, E36A, T39E, V60I, K122E, D123S, I135T, E138A, R172RK, K173T, Q174K, T200A, E203K, Q207E, R211K, D218DE, V245Q, E248D, A272P, K275R, Q278H, E291D, V292I, I293V, V317VG, Y319X | G316E |
| >TK3035| codons 1-324 PISPIETVPVKLKPGMDGPKVKQWPLTEEKIKALTAICEELEKEGKISKIGPENPYNTPI FAIKKKNSTRWRKIVDFRELNKRTQDFWEVQLGIPHPAGLEKKKSVTVLDVGDAYFSVPL DESFRKYTAFTIPSTNNATPGIRYQYNVLPQGWKGSPAIFQSSMTKILEPFKTKNPDIVI YQYMDDLYVASDLEIGQHRAKIKELREHLWKWGFYTPEEKHQKEPPFLWMGYELHPDTWT VQPIQLPDKDSWTVNDIQKLVGKLNWASQIYPGIRVKHLCKLLRGTKALTDIVPLTEEAE LELAENREILKEPVHEGYXDPSKD |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| I54A, V82A | L10I, T12S, I15V, L19I, K20R, E35D, M36I, R41K, K45KR, D60E, L63P, H69K, A71V, L89M, I93L |
| >TK3035| codons 1-99 PQITLWQRPIVSIKVGGQIREALLDTGADDTVLEDINLPGKWKPRMIGGIGGFAKVRQYE QIPIEICGKKVIGTVLVGPTPANIIGRNMLTQLGCTLNF |
References
| Author | Title | Citation |
| Non-B Workgroup | Impact of HIV-1 subtype and antiretroviral therapy on protease and reverse transcriptase genotype: Results of a global collaboration. | PLoS Med, 2005 |