<!--#if expr="$title" --> <!--#echo var="title" --> <!--#else --> HIV Drug Resistance Database <!--#endif -->
Stanford University HIV Drug Resistance Database - A curated public database designed to represent, store, and analyze the divergent forms of data underlying HIV drug resistance.

Isolate Data

Patient Isolate Region Year Species Subtype Source Clone Method
TK3033 TK3033a Denmark 2003 HIV1 A Plasma None

Treatment History
Order Regimen Weeks
1 3TC+ AZT+ NFV 1
2 None 80
3 3TC+ AZT+ EFV 66
4 EFV 22
5 3TC+ ABC+ AZT 15

RT Sequence
NRTIMajorDRMs NRTIMinorDRMs NNRTIMajorDRMs NNRTIMinorDRMs Polys UnusualMuts
D67DN   K103N   V35T, V60I, K122E, D123S, K166R, K173S, D177E, T200A, Q207A, R211S, T215X, V245A, S251H, A272P, K277R, T286A, E291D, V292I, I293V  
>TK3033a| codons 1-324
PISPIETVPVKLKPGMDGPKVKQWPLTEEKIKALTEICTEMEKEGKISKIGPENPYNTPI
FAIKKKNSTKWRKLVDFRELNKRTQDFWEVQLGIPHPAGLKKNKSVTVLDVGDAYFSVPL
DESFRKYTAFTIPSINNETPGIRYQYNVLPQGWKGSPAIFQSSMTRILEPFRSQNPEIVI
YQYMDDLYVGSDLEIGQHRAKIEELRAHLLSWGFXTPDKKHQKEPPFLWMGYELHPDKWT
VQPIALPEKDHWTVNDIQKLVGKLNWASQIYPGIKVRQLCKLLRGAKALTDIVPLTEEAE
LELAENREILKEPVHGVYYDPSKD

Protease Sequence
PIMajorDRMs PIMinorDRMs Polys UnusualMuts
    I13V, K20KR, E35D, M36I, R41K, R57K, H69K, L89M  
>TK3033a| codons 1-99
PQITLWQRPLVTVKIGGQLREALLDTGADDTVLEDINLPGKWKPKMIGGIGGFIKVKQYD
QILIEICGKKAIGTVLVGPTPVNIIGRNMLTQIGCTLNF

References
Author Title Citation
Non-B Workgroup Impact of HIV-1 subtype and antiretroviral therapy on protease and reverse transcriptase genotype: Results of a global collaboration. PLoS Med, 2005