Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| TK3029 | TK3029 | Denmark | 2000 | HIV1 | CRF45_cpx | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | 3TC+ AZT+ SQV | 106 |
| 2 | D4T+ DDI+ NFV | 26 |
| 3 | D4T+ NFV+ 3TC | 17 |
| 4 | D4T+ ABC+ EFV | 50 |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| L90M | L10V, I13V, K20T, E35D, M36I, R41K, H69K, T74S, L89I |
| >TK3029| codons 1-98 PQITLWQRPVVTVKIGGQLTEALLDTGADDTVLEDINLPGKWKPKMIGGIGGFIKVRQYD QILIEICGKKAIGSVLVGPTPVNIIGRNIMTQIGCTLN |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| M41L, D67N, K70R, L210LW, T215F | V75M, K219Q | K103N, G190A | E6D, K20R, V35T, K49R, V60I, V90I, I94L, S117A, K122E, D123S, I135T, S162D, K173S, Q174K, D177E, V179I, Q207A, R211N, D218E, L228H, V245K, D250E, A272G, T286A, E291D, I293V, P294T, E312D |
| >TK3029| codons 1-324 PISPIDTVPVKLKPGMDGPRVKQWPLTEEKIKALTEICTELEKEGKISRIGPENPYNTPI FAIKKKNSTRWRKLMDFRELNKRTQDFWEIQLGLPHPAGLKKNKSVTVLDVGDAYFAVPL DESFRKYTAFTIPSTNNETPGIRYQYNVLPQGWKGSPAIFQDSMTKILEPFRSKNPEIII YQYMDDLYVASDLEIGQHRTKIEELRAHLWNWGFFTPEQKHQKEPPFHWMGYELHPDKWT VQPIKLPEKESWTVNDIQKLVGKLNWASQIYGGIKVKQLCKLLRGAKALTDVVTLTEEAE LELAENREILKDPVHGVYYDPSKD |
References
| Author | Title | Citation |
| Non-B Workgroup | Impact of HIV-1 subtype and antiretroviral therapy on protease and reverse transcriptase genotype: Results of a global collaboration. | PLoS Med, 2005 |