<!--#if expr="$title" --> <!--#echo var="title" --> <!--#else --> HIV Drug Resistance Database <!--#endif -->
Stanford University HIV Drug Resistance Database - A curated public database designed to represent, store, and analyze the divergent forms of data underlying HIV drug resistance.

Isolate Data

Patient Isolate Region Year Species Subtype Source Clone Method
TK3027 TK3027b Denmark 2003 HIV1 C Plasma None

Treatment History
Order Regimen Weeks
1 3TC+ D4T+ RTV 7
2 None 9
3 3TC+ D4T+ SQV 33
4 3TC+ D4T+ NFV 176
5 3TC+ AZT+ EFV+ LPV 60

RT Sequence
NRTIMajorDRMs NRTIMinorDRMs NNRTIMajorDRMs NNRTIMinorDRMs Polys UnusualMuts
M41ML, D67DN, M184V   K103N   V35T, E36EA, T39E, S48T, K122E, D123DG, I135M, K173A, D177E, I178V, T200A, I202V, E204K, Q207D, R211RK, T215X, V245Q, A272P, K277R, T286A, E291D, V292I, I293V, V317VA  
>TK3027b| codons 1-333
PISPIETVPVKLKPGMDGPKVKQWPLTEEKIKALTAICEELEKEGKITKIGPENPYNTPV
FAIKKKNSTKWRKLVDFRELNKRTQDFWEVQLGIPHPAGLKKNKSVTVLDVGDAYFSVPL
DEGFRKYTAFTIPSMNNETPGIRYQYNVLPQGWKGSPAIFQSSMTKILEPFRAQNPEVVI
YQYVDDLYVGSDLEIGQHRAKVEKLRDHLLKWGFXTPDKKHQKEPPFLWMGYELHPDKWT
VQPIQLPEKDSWTVNDIQKLVGKLNWASQIYPGIKVRQLCKLLRGAKALTDIVPLTEEAE
LELAENREILKEPVHGAYYDPSKDLIAEIQKQG

Protease Sequence
PIMajorDRMs PIMinorDRMs Polys UnusualMuts
D30DN, L90LM N88D T12S, I13IV, I15V, L19I, K20R, E35D, M36I, N37ND, R41RK, L63P, H69K, T74S, L89IM, I93L  
>TK3027b| codons 1-99
PQITLWQRPLVSVKVGGQIREALLDTGADNTVLEDIDLPGKWKPKMIGGIGGFIKVRQYD
QIPIEICGKKAIGSVLVGPTPVNIIGRDIMTQLGCTLNF

References
Author Title Citation
Non-B Workgroup Impact of HIV-1 subtype and antiretroviral therapy on protease and reverse transcriptase genotype: Results of a global collaboration. PLoS Med, 2005