Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| TK3027 | TK3027b | Denmark | 2003 | HIV1 | C | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | 3TC+ D4T+ RTV | 7 |
| 2 | None | 9 |
| 3 | 3TC+ D4T+ SQV | 33 |
| 4 | 3TC+ D4T+ NFV | 176 |
| 5 | 3TC+ AZT+ EFV+ LPV | 60 |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| D30DN, L90LM | N88D | T12S, I13IV, I15V, L19I, K20R, E35D, M36I, N37ND, R41RK, L63P, H69K, T74S, L89IM, I93L |
| >TK3027b| codons 1-99 PQITLWQRPLVSVKVGGQIREALLDTGADNTVLEDIDLPGKWKPKMIGGIGGFIKVRQYD QIPIEICGKKAIGSVLVGPTPVNIIGRDIMTQLGCTLNF |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| M41ML, D67DN, M184V | K103N | V35T, E36EA, T39E, S48T, K122E, D123DG, I135M, K173A, D177E, I178V, T200A, I202V, E204K, Q207D, R211RK, T215X, V245Q, A272P, K277R, T286A, E291D, V292I, I293V, V317VA |
| >TK3027b| codons 1-333 PISPIETVPVKLKPGMDGPKVKQWPLTEEKIKALTAICEELEKEGKITKIGPENPYNTPV FAIKKKNSTKWRKLVDFRELNKRTQDFWEVQLGIPHPAGLKKNKSVTVLDVGDAYFSVPL DEGFRKYTAFTIPSMNNETPGIRYQYNVLPQGWKGSPAIFQSSMTKILEPFRAQNPEVVI YQYVDDLYVGSDLEIGQHRAKVEKLRDHLLKWGFXTPDKKHQKEPPFLWMGYELHPDKWT VQPIQLPEKDSWTVNDIQKLVGKLNWASQIYPGIKVRQLCKLLRGAKALTDIVPLTEEAE LELAENREILKEPVHGAYYDPSKDLIAEIQKQG |
References
| Author | Title | Citation |
| Non-B Workgroup | Impact of HIV-1 subtype and antiretroviral therapy on protease and reverse transcriptase genotype: Results of a global collaboration. | PLoS Med, 2005 |