Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| CA1838 | CA4941 | U.S. | 1998 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | AZT | 148 |
| 2 | AZT+DDC | 61 |
| 3 | D4T+DDI | 113 |
| 4 | 3TC+D4T+SQV | 30 |
| 5 | 3TC+D4T+IDV | 82 |
| 6 | DDI+DLV+NFV+SQV | 28 |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| M46I, I84V, L90M | G73S | L10I, K20I, E35D, N37S, I62V, L63P, A71I, I93L |
| >CA4941| codons 1-99 PQITLWQRPIVTIKIGGQLIEALLDTGADDTVLEDMSLPGRWKPKIIGGIGGFIKVRQYD QVPIEICGHKIISTVLVGPTPVNVIGRNLMTQLGCTLNF |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| D67N, M184V, L210W, T215Y | K103N | K20R, V35IM, K102Q, K122E, S162C, T200A, E203K, Q207E, R211K, K223E, K277R, A288S, I293V | K154K*, T286AG |
| >CA4940| codons 1-295 PISPIETVPVKLKPGMDGPRVKQWPLTEEKIKALMEICTEMEKEGKISKIGPENPYNTPV FAIKKKNSTKWRKLVDFRELNKRTQDFWEVQLGIPHPAGLKQNKSVTVLDVGDAYFSVPL DEDFRKYTAFTIPSINNETPGIRYQYNVLPQGW*GSPAIFQCSMTKILEPFRKQNPDIVI YQYVDDLYVGSDLEIGQHRAKIKELREHLWKWGFYTPDKKHQEEPPFLWMGYELHPDKWT VQPIVLPEKDSWTVNDIQKLVGKLNWASQIYAGIKVRQLCKLLRGGKSLTEVVPL |
References
| Author | Title | Citation |
| Gonzales, MJ | HIV-1 reverse transcriptase and protease subtypes: classification, amino acid mutation patterns, and prevalence in a Northern California clinic-based population. | J Infect Dis, 2001 |
| Rhee, SY | HIV-1 Protease and Reverse Transcriptase Mutations: Correlations with Antiretroviral Therapy in Subtype B Isolates and Implications for Drug-Resistance Surveillance. | J Infect Dis, 2005 |