Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| TK3022 | TK3022 | Denmark | 2001 | HIV1 | C | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | DDC+ SQV | 20 |
| 2 | None | 29 |
| 3 | 3TC+ AZT+ SQV | 52 |
| 4 | 3TC+ D4T+ NFV | 31 |
| 5 | 3TC+ AZT+ EFV | 57 |
| 6 | None | 13 |
| 7 | 3TC+ AZT+ EFV | 30 |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| D67N, K70R, M184V | K219E | G190S | K22KR, V35M, T39E, S48T, V90I, K101KQ, K122E, D123S, A158S, K173T, Q174K, D177E, I178L, V179VI, I195L, T200A, V245Q, S251I, A272P, K275R, L283I, E291D, V292I, I293V |
| >TK3022| codons 1-324 PISPIETVPVKLKPGMDGPKVRQWPLTEEKIKALMEICEEMEKEGKITKIGPENPYNTPV FAIKKKNSTRWRKLVDFRELNKRTQDFWEIQLGIPHPAGLQKKKSVTVLDVGDAYFSVPL DESFRKYTAFTIPSINNETPGIRYQYNVLPQGWKGSPSIFQSSMTKILEPFRTKNPELII YQYVDDLYVSSDLELGQHRAKIEELRQHLLRWGFTTPDEKHQKEPPFLWMGYELHPDKWT VQPIQLPEKDIWTVNDIQKLVGKLNWASQIYPGIRVKQLCKLIRGTKALTDIVPLTEEAE LELAENREILKEPVHGVYYDPSKD |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| T12S, I15V, L19I, K20R, E35D, M36I, K43R, L63T, H69K, L89M, L97LI |
| >TK3022| codons 1-99 PQITLWQRPLVSIKVGGQIREALLDTGADDTVLEDINLPGRWRPKMIGGIGGFIKVRQYD QITIEICGKKAIGTVLVGPTPVNIIGRNMLTQIGCTINF |
References
| Author | Title | Citation |
| Non-B Workgroup | Impact of HIV-1 subtype and antiretroviral therapy on protease and reverse transcriptase genotype: Results of a global collaboration. | PLoS Med, 2005 |