Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| TK3020 | TK3020a | Denmark | 2001 | HIV1 | C | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | 3TC+ D4T+ RTV | 57 |
| 2 | 3TC+ D4T+ NFV | 14 |
| 3 | 3TC+ D4T+ SQV | 18 |
| 4 | D4T+ SQV+ DDI | 31 |
| 5 | DDI+ ABC+ EFV | 91 |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| T12S, I15V, L19I, E35D, M36I, R41K, L63T, H69K, T74S, L89I, I93L |
| >TK3020a| codons 1-99 PQITLWQRPLVSIKVGGQIKEALLDTGADDTVLEDINLPGKWKPKMIGGIGGFIKVRQYD QITIEICGKKAIGSVLVGPTPVNIIGRNILTQLGCTLNF |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| D67N, T69D, K70R, L74V, Y115F, M184V | K219Q | K103N, Y188L | V21VA, V35T, E36A, T39E, S48T, V60I, S68R, K122E, D123N, I135T, E138D, S162Y, K173T, Q174K, D177G, T200A, E203K, Q207E, R211K, K223Q, V245Q, E248D, A272P, Q278A, K281R, T286AP, E291D, V292I, I293V, D324E | K13KT, K20KM, P25A, E42EAD |
| >TK3020a| codons 1-324 PISPIETVPVKLTPGMDGPMAKQWALTEEKIKALTAICEEMDKEGKITKIGPENPYNTPI FAIKKKNRDRWRKVVDFRELNKRTQDFWEVQLGIPHPAGLKKNKSVTVLDVGDAFFSVPL DENFRKYTAFTIPSTNNDTPGIRYQYNVLPQGWKGSPAIFQYSMTKILEPFRTKNPGIVI YQYVDDLLVGSDLEIGQHRAKIKELREHLLKWGFTTPDQKHQQEPPFLWMGYELHPDKWT VQPIQLPDKDSWTVNDIQKLVGKLNWASQIYPGIKVKALCRLLRGPKALTDIVPLTEEAE LELAENREILKEPVHGVYYDPSKE |
References
| Author | Title | Citation |
| Non-B Workgroup | Impact of HIV-1 subtype and antiretroviral therapy on protease and reverse transcriptase genotype: Results of a global collaboration. | PLoS Med, 2005 |