Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| TK3019 | TK3019 | Denmark | 2000 | HIV1 | C | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | D4T+ DDI+ SQV | 61 |
| 2 | AZT+ NFV+ NVP | 2 |
| 3 | None | 12 |
| 4 | 3TC+ AZT+ NFV | 29 |
| 5 | ABC+ EFV+ RTV+ SQV | 51 |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| M41L, D67N, T69D, K70R, L74V, M184V, T215Y | L100I, K103N | A98G | D17DE, V35T, T39A, E44D, S48T, V60I, K122E, D123S, K173A, Q174R, G196K, T200A, Q207E, H208Y, W212M, D218E, V245Q, A272P, K277R, E291D, V292I, I293V | G18GV |
| >TK3019| codons 1-324 PISPIETVPVKLKPGMEVPKVKQWPLTEEKIKALTEICAELEKDGKITKIGPENPYNTPI FAIKKKNSDRWRKVVDFRELNKRTQDFWEVQLGIPHPGGIKKNKSVTVLDVGDAYFSVPL DESFRKYTAFTIPSINNETPGIRYQYNVLPQGWKGSPAIFQSSMTKILEPFRARNPDIVI YQYVDDLYVGSDLEIKQHRAKIEELREYLLRMGFYTPEKKHQKEPPFLWMGYELHPDKWT VQPIQLPEKDSWTVNDIQKLVGKLNWASQIYPGIKVRQLCKLLRGTKALTDIVPLTEEAE LELAENREILKEPVHGVYYDPSKD |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| I54V, I84IV, L90M | V11VI, G73S | L10I, I13V, I15V, L19I, K20R, E35D, M36I, R41K, K45R, I62V, L63P, H69T, A71V, I72L, I93L |
| >TK3019| codons 1-99 PQITLWQRPIITVKVGGQIREALLDTGADDTVLEDINLPGKWKPRMIGGIGGFVKVRQYD QVPIEICGTKVLSTVLVGPTPVNVIGRNLMTQLGCTLNF |
References
| Author | Title | Citation |
| Non-B Workgroup | Impact of HIV-1 subtype and antiretroviral therapy on protease and reverse transcriptase genotype: Results of a global collaboration. | PLoS Med, 2005 |