Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| TK3016 | TK3016 | Denmark | 2001 | HIV1 | C | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | 3TC+ AZT+ SQV | 93 |
| 2 | D4T+ DDI+ NFV | 12 |
| 3 | NFV+ 3TC+ AZT | 1 |
| 4 | 3TC+ AZT+ SQV | 61 |
| 5 | 3TC+ AZT+ EFV | 28 |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| I54V, L90M | T74P | L10V, I15V, E35D, M36I, R41K, H69K, A71V, L89M, I93L |
| >TK3016| codons 1-99 PQITLWQRPVVTIKVGGQLKEALLDTGADDTVLEDINLPGKWKPKMIGGIGGFVKVRQYD QILIEICGKKVIGPVLVGPTPVNIIGRNMMTQLGCTLNF |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| D67N, K70R, M184V | K219Q | K103N, V106M | E6A, V35T, E36A, T39E, A98S, K122E, D123S, I135T, A158S, K173A, D177E, E203D, Q207E, R211K, D218E, V245Q, D250E, A272P, V276I, K277R, T286A, E291D, V292I, I293V |
| >TK3016| codons 1-324 PISPIATVPVKLKPGMDGPKVKQWPLTEEKIKALTAICEEMEKEGKISKIGPENPYNTPV FAIKKKNSTRWRKLVDFRELNKRTQDFWEVQLGIPHPSGLKKNKSMTVLDVGDAYFSVPL DESFRKYTAFTIPSTNNETPGIRYQYNVLPQGWKGSPSIFQSSMTKILEPFRAQNPEIVI YQYVDDLYVGSDLEIGQHRTKIDELREHLLKWGFTTPEQKHQKEPPFLWMGYELHPDKWT VQPIQLPEKESWTVNDIQKLVGKLNWASQIYPGIKIRQLCKLLRGAKALTDIVPLTEEAE LELAENREILKEPVHGVYYDPSKD |
References
| Author | Title | Citation |
| Non-B Workgroup | Impact of HIV-1 subtype and antiretroviral therapy on protease and reverse transcriptase genotype: Results of a global collaboration. | PLoS Med, 2005 |