Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| TK3015 | TK3015c | Denmark | 2004 | HIV1 | C | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | 3TC+ AZT+ SQV | 43 |
| 2 | AZT+ DDC+ IDV | 173 |
| 3 | ABC+ EFV+ LPV | 126 |
| 4 | ABC+ EFV+ LPV+ RTV+ NVP+ TDF+ TPV | 27 |
| 5 | ABC+ EFV+ LPV+ RTV+ TDF+ TPV | 1 |
| 6 | ABC+ EFV+ LPV | 2 |
| 7 | ABC+ EFV+ LPV+ RTV+ TDF+ TPV | 3 |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| M41L, D67N, L210W, T215Y | K219R | V106M | V179D, F227L | E6K, V35M, T39D, E44D, K102KR, V118I, K122E, I135L, K173A, Q174KR, N175NY, D177E, V189VI, E194K, G196E, T200A, I202V, Q207E, R211K, V245Q, D250E, A272S, K281KR, T286A, E291D, V292I, I293V, H315F |
| >TK3015c| codons 1-333 PISPIKTVPVKLKPGMDGPKVKQWPLTEEKIKALMEICDELEKDGKISKIGPENPYNTPV FAIKKKNSTKWRKLVDFRELNKRTQDFWEVQLGIPHPAGLKRKKSMTVLDVGDAYFSIPL DEDFRKYTAFTIPSLNNETPGIRYQYNVLPQGWKGSPAIFQSSMTKILEPFRAKYPEIDI YQYMDDLYIGSDLKIEQHRAKVEELREHLWKWGFYTPDRKHQKEPPLLWMGYELHPDKWT VQPIQLPEKESWTVNDIQKLVGKLNWASQIYSGIKVKQLCRLLRGAKALTDIVPLTEEAE LELAENREILKEPVFGVYYDPSKDLIAEIQKQG |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| I54V, V82T, I84IV, L90M | K43T | L10I, T12S, I15V, L19I, K20IR, E35D, M36I, R41K, D60E, Q61E, L63P, H69K, A71V, I85V, L89LM, I93L |
| >TK3015c| codons 1-99 PQITLWQRPIVSIKVGGQIIEALLDTGADDTVLEDINLPGKWTPKMIGGIGGFVKVRQYE EIPIEICGKKVIGTVLVGPTPTNVVGRNMMTQLGCTLNF |
References
| Author | Title | Citation |
| Non-B Workgroup | Impact of HIV-1 subtype and antiretroviral therapy on protease and reverse transcriptase genotype: Results of a global collaboration. | PLoS Med, 2005 |