Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| TK3015 | TK3015b | Denmark | 2002 | HIV1 | C | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | 3TC+ AZT+ SQV | 43 |
| 2 | AZT+ DDC+ IDV | 173 |
| 3 | ABC+ EFV+ LPV | 67 |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| I54V, V82A, L90M | L10F, K43T | T12P, I15V, L19K, K20I, E35D, M36I, R41K, D60E, Q61E, L63P, H69K, A71V, I85V, I93L |
| >TK3015b| codons 1-99 PQITLWQRPFVPIKVGGQKIEALLDTGADDTVLEDINLPGKWTPKMIGGIGGFVKVRQYE EIPIEICGKKVIGTVLVGPTPANIVGRNLMTQLGCTLNF |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| M41L, D67N, L210W, T215Y | V106M | V179D | E6EK, V35M, T39D, E44D, V118I, K122E, I135L, K173A, Q174K, N175Y, D177E, E194K, G196E, T200A, I202V, Q207E, R211K, V245Q, D250E, I257IV, A272S, K281KR, T286A, E291D, V292I, I293V, H315F |
| >TK3015b| codons 1-320 PISPIKTVPVKLKPGMDGPKVKQWPLTEEKIKALMEICDELEKDGKISKIGPENPYNTPV FAIKKKNSTKWRKLVDFRELNKRTQDFWEVQLGIPHPAGLKKKKSMTVLDVGDAYFSIPL DEDFRKYTAFTIPSLNNETPGIRYQYNVLPQGWKGSPAIFQSSMTKILEPFRAKYPEIDI YQYMDDLYVGSDLKIEQHRAKVEELREHLWKWGFYTPDKKHQKEPPFLWMGYELHPDKWT VQPIQLPEKESWTVNDVQKLVGKLNWASQIYSGIKVKQLCRLLRGAKALTDIVPLTEEAE LELAENREILKEPVFGVYYD |
References
| Author | Title | Citation |
| Non-B Workgroup | Impact of HIV-1 subtype and antiretroviral therapy on protease and reverse transcriptase genotype: Results of a global collaboration. | PLoS Med, 2005 |