Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| TK3010 | TK3010a | Denmark | 2001 | HIV1 | C | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | D4T+ DDC+ SQV | 36 |
| 2 | None | 30 |
| 3 | D4T+ DDI+ NFV | 30 |
| 4 | D4T+ NFV+ 3TC | 32 |
| 5 | ABC+ EFV+ IDV+ RTV | 36 |
| 6 | ABC+ EFV+ LPV | 50 |
| 7 | ABC+ 3TC+ AZT+ NFV | 26 |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| D67N, T69D, K70R | V75I, K219Q | L100I, K103N | A98G | V35T, E36A, T39D, S48T, V60I, K122E, D123G, I135V, S162C, K166KR, K173T, Q174K, D177E, I178L, T200A, E203K, Q207E, R211K, V245Q, A272P, V292I, I293V, K311R, V317A, Q334H, G335D, Q340X, Y342X |
| >TK3010a| codons 1-342 PISPIETVPVKLKPGMDGPKVKQWPLTEEKIKALTAICDEMEKEGKITKIGPENPYNTPI FAIKKKNSDRWRKLIDFRELNKRTQDFWEVQLGIPHPGGIKKNKSVTVLDVGDAYFSVPL DEGFRKYTAFTIPSVNNETPGIRYQYNVLPQGWKGSPAIFQCSMTRILEPFRTKNPELVI YQYMDDLYVGSDLEIGQHRAKIKELREHLLKWGFTTPDQKHQKEPPFLWMGYELHPDKWT VQPIQLPEKDSWTVNDIQKLVGKLNWASQIYPGIKVKQLCKLLRGTKALTEIVPLTEEAE LELAENREILREPVHGAYYDPSKDLIAEIQKQGHDQWTYXIX |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| T12S, I15V, L19I, K20T, E35ED, M36I, R41K, L63P, H69K, L89M, I93L |
| >TK3010a| codons 1-99 PQITLWQRPLVSIKVGGQITEALLDTGADDTVLEDINLPGKWKPKMIGGIGGFIKVRQYD QIPIEICGKKAIGTVLVGPTPVNIIGRNMLTQLGCTLNF |
References
| Author | Title | Citation |
| Non-B Workgroup | Impact of HIV-1 subtype and antiretroviral therapy on protease and reverse transcriptase genotype: Results of a global collaboration. | PLoS Med, 2005 |