<!--#if expr="$title" --> <!--#echo var="title" --> <!--#else --> HIV Drug Resistance Database <!--#endif -->
Stanford University HIV Drug Resistance Database - A curated public database designed to represent, store, and analyze the divergent forms of data underlying HIV drug resistance.

Isolate Data

Patient Isolate Region Year Species Subtype Source Clone Method
TK3010 TK3010 Denmark 2001 HIV1 C Plasma None

Treatment History
Order Regimen Weeks
1 D4T+ DDC+ SQV 36
2 None 30
3 D4T+ DDI+ NFV 30
4 D4T+ NFV+ 3TC 32
5 ABC+ EFV+ IDV+ RTV 36
6 ABC+ EFV+ LPV 43

RT Sequence
NRTIMajorDRMs NRTIMinorDRMs NNRTIMajorDRMs NNRTIMinorDRMs Polys UnusualMuts
D67N, T69D, K70R K219Q L100I, K103N A98G T7S, V35T, E36A, T39E, S48T, V60I, K122E, D123G, I135V, T165TI, K173T, Q174K, D177E, I178L, T200A, E203K, Q207E, R211K, V245Q, A272P, T286TA, V292I, I293V, K311R, V317A, Q334H, G335D A129G, N136H
>TK3010| codons 1-340
PISPIESVPVKLKPGMDGPKVKQWPLTEEKIKALTAICEEMEKEGKITKIGPENPYNTPI
FAIKKKNSDRWRKLVDFRELNKRTQDFWEVQLGIPHPGGIKKNKSVTVLDVGDAYFSVPL
DEGFRKYTGFTIPSVHNETPGIRYQYNVLPQGWKGSPAIFQSSMIKILEPFRTKNPELVI
YQYMDDLYVGSDLEIGQHRAKIKELREHLLKWGFTTPDQKHQKEPPFLWMGYELHPDKWT
VQPIQLPEKDSWTVNDIQKLVGKLNWASQIYPGIKVKQLCKLLRGAKALTEIVPLTEEAE
LELAENREILREPVHGAYYDPSKDLIAEIQKQGHDQWTYQ

Protease Sequence
PIMajorDRMs PIMinorDRMs Polys UnusualMuts
    T12S, I15V, L19I, K20T, M36I, R41K, L63P, H69K, L89M, I93L  
>TK3010| codons 1-99
PQITLWQRPLVSIKVGGQITEALLDTGADDTVLEEINLPGKWKPKMIGGIGGFIKVRQYD
QIPIEICGKKAIGTVLVGPTPVNIIGRNMLTQLGCTLNF

References
Author Title Citation
Non-B Workgroup Impact of HIV-1 subtype and antiretroviral therapy on protease and reverse transcriptase genotype: Results of a global collaboration. PLoS Med, 2005