Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| TK3008 | TK3008 | Denmark | 2003 | HIV1 | D | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | 3TC+ AZT+ SQV | 98 |
| 2 | 3TC+ AZT+ NFV | 246 |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| M184V | P225H | V35T, T39A, V60VI, D121CY, K122E, D123DE, I135IL, I142V, D177E, I178M, T200I, Q207E, R211K, F214FLV, V245E, E248D, D250DE, A272P, K277R, L282C, I293V, E297K, Q334QH | Q91QH |
| >TK3008| codons 1-334 PISPIETVPVKLKPGMDGPKVKQWPLTEEKIKALTEICAEMEKEGKISKIGPENPYNTPI FAIKKKDSTKWRKLVDFRELNKRTQDFWEVHLGIPHPAGLKKKKSVTVLDVGDAYFSVPL YEEFRKYTAFTIPSLNNETPGVRYQYNVLPQGWKGSPAIFQSSMTKILEPFRKQNPEMVI YQYVDDLYVGSDLEIGQHRIKIEELREHLLKWGVTTPDKKHQKEHPFLWMGYELHPDKWT VQPIELPDKESWTVNDIQKLVGKLNWASQIYPGIKVRQLCKCLRGTKALTEVVPLTKEAE LELAENREILKEPVHGVYYDPSKDLIAEIQKQGH |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| I84V | N83D | L10I, I13V, A22V, M36I, R41K, I62V, L63P, I64V, H69HY |
| >TK3008| codons 1-99 PQITLWQRPIVTVKIGGQLKEVLLDTGADDTVLEEINLPGKWKPKMIGGIGGFIKVRQYD QVPVEICGYKAIGTVLVGPTPVDVIGRNLLTQIGCTLNF |
References
| Author | Title | Citation |
| Non-B Workgroup | Impact of HIV-1 subtype and antiretroviral therapy on protease and reverse transcriptase genotype: Results of a global collaboration. | PLoS Med, 2005 |