Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| TK3002 | TK3002b | Denmark | 2003 | HIV1 | CRF02_AG | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | 3TC+ AZT+ RTV+ SQV | 55 |
| 2 | None | 16 |
| 3 | 3TC+ AZT+ RTV+ SQV | 65 |
| 4 | 3TC+ AZT+ RTV+ IDV | 93 |
| 5 | 3TC+ AZT+ ABC | 47 |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| L10IV, I13V, L19P, K20I, E35ED, M36I, R41K, L63LP, H69K, K70KR, L89M |
| >TK3002b| codons 1-99 PQITLWQRPIVTVKIGGQPIEALLDTGADDTVLEDINLPGKWKPKMIGGIGGFIKVRQYD QIPIEICGKRAIGTVLVGPTPVNIIGRNMLTQIGCTLNF |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| V35T, E36D, V60VI, I135V, S162A, K173T, Q174K, D177E, T200R, E203D, Q207D, R211K, P243T, V245E, E248D, K281R, T286A, E291D, V292I, I293V, P294PT, S322A, I326V |
| >TK3002b| codons 1-334 PISPIETVPVKLKPGMDGPKVKQWPLTEEKIKALTDICTEMEKEGKISKIGPENPYNTPI FAIKKKDSTKWRKLVDFRELNKRTQDFWEVQLGIPHPAGLKKKKSVTVLDVGDAYFSVPL DKDFRKYTAFTIPSVNNETPGIRYQYNVLPQGWKGSPAIFQASMTKILEPFRTKNPEIVI YQYMDDLYVGSDLEIGQHRRKIDELRDHLLKWGFTTPDKKHQKEPPFLWMGYELHPDKWT VQTIELPDKDSWTVNDIQKLVGKLNWASQIYAGIKVKQLCRLLRGAKALTDIVTLTEEAE LELAENREILKEPVHGVYYDPAKDLVAEIQKQGQ |
References
| Author | Title | Citation |
| Non-B Workgroup | Impact of HIV-1 subtype and antiretroviral therapy on protease and reverse transcriptase genotype: Results of a global collaboration. | PLoS Med, 2005 |