Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| TK2028 | TK2028 | Denmark | 2001 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | AZT+ DDI | 21 |
| 2 | AZT+ DDI+ IDV | 8 |
| 3 | AZT+ IDV+ 3TC | 43 |
| 4 | 3TC+ D4T+ RTV+ SQV | 156 |
| 5 | 3TC+ ABC+ DDI+ EFV | 35 |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| M41L, D67N, L74V, M184V, T215Y | L100I, K103N | V108VI | V35L, T39A, D123E, K173R, D177E, H221Y, A272P, K277R, E297K | K219A |
| >TK2028| codons 1-319 PISPIETVPVKLKPGMDGPKVKQWPLTEEKIKALLEICAELEKEGKISKIGPENPYNTPV FAIKKKNSTKWRKVVDFRELNKRTQDFWEVQLGIPHPAGIKKNKSVTILDVGDAYFSVPL DKEFRKYTAFTIPSINNETPGIRYQYNVLPQGWKGSPAIFQSSMTKILEPFRRQNPEIVI YQYVDDLYVGSDLEIGQHRTKIEELRQHLLRWGFYTPDAKYQKEPPFLWMGYELHPDKWT VQPIVLPEKDSWTVNDIQKLVGKLNWASQIYPGIKVRQLCKLLRGTKALTEVIPLTKEAE LELAENREILKEPVHGVYY |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| M46MI, I54V, L90LM | L23I, F53L, N88ND | K14KR, E35ED, N37P, L63P, A71AV |
| >TK2028| codons 1-99 PQITLWQRPLVTIRIGGQLKEAILDTGADDTVLEDMPLPGRWKPKIIGGIGGLVKVRQYD QIPIEICGHKVIGTVLVGPTPVNIIGRDLMTQIGCTLNF |
References
| Author | Title | Citation |
| Non-B Workgroup | Impact of HIV-1 subtype and antiretroviral therapy on protease and reverse transcriptase genotype: Results of a global collaboration. | PLoS Med, 2005 |