Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| TK2025 | TK2025a | Denmark | 2004 | HIV1 | D | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | 3TC+ D4T+ IDV | 8 |
| 2 | None | 31 |
| 3 | 3TC+ D4T+ IDV | 25 |
| 4 | IDV | 7 |
| 5 | 3TC+ ABC+ D4T+ RTV | 1 |
| 6 | 3TC+ ABC+ D4T+ RTV+ NVP+ SQV | 5 |
| 7 | None | 3 |
| 8 | 3TC+ ABC+ D4T+ NVP+ RTV+ SQV | 105 |
| 9 | ABC+ D4T+ DDC+ DDI+ EFV+ LPV | 196 |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| M41L, L74V | K101E, Y181C, G190A | K32R, V35R, K43N, V60I, V118I, K122E, I135T, D177E, T200I, Q207E, R211K, V245K, D250E, A272P, L282C, R284K, T286A, I293V, E297A, P321PQ |
| >TK2025a| codons 1-334 PISPIETVPVKLKPGMDGPKVKQWPLTEEKIRALREICTELENEGKISKIGPENPYNTPI FAIKKKDSTKWRKVVDFRELNKRTQDFWEVQLGIPHPAGLEKKKSVTVLDVGDAYFSIPL DEDFRKYTAFTIPSTNNETPGIRYQYNVLPQGWKGSPAIFQSSMTKILEPFRKQNPEIVI CQYMDDLYVASDLEIGQHRIKIEELREHLLKWGFTTPDKKHQKEPPFLWMGYELHPDKWT VQPIKLPEKESWTVNDIQKLVGKLNWASQIYPGIKVKQLCKCLKGAKALTEVVPLTAEAE LELAENREILKEPVHGVYYDQSKDLIAEIQKQGQ |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| L10I, I13V, M36I, R41K, D60E, L63T, I64V, I72V |
| >TK2025a| codons 1-99 PQITLWQRPIVTVKIGGQLKEALLDTGADDTVLEEINLPGKWKPKMIGGIGGFIKVRQYE QITVEICGHKAVGTVLVGPTPVNIIGRNLLTQIGCTLNF |
References
| Author | Title | Citation |
| Non-B Workgroup | Impact of HIV-1 subtype and antiretroviral therapy on protease and reverse transcriptase genotype: Results of a global collaboration. | PLoS Med, 2005 |