Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| TK2024 | TK2024b | Denmark | 2003 | HIV1 | C | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | 3TC+ D4T+ IDV | 48 |
| 2 | None | 13 |
| 3 | 3TC+ D4T+ IDV | 72 |
| 4 | 3TC+ IDV+ AZT+ DDI+ EFV+ RTV | 91 |
| 5 | 3TC+ AZT+ DDI+ EFV+ RTV+ SQV | 5 |
| 6 | None | 14 |
| 7 | 3TC+ AZT+ DDI+ EFV+ RTV+ SQV | 59 |
| 8 | None | 9 |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| T12S, I15V, L19I, E35D, M36I, N37ND, R41RK, L63LP, H69K, L89M, I93IL |
| >TK2024b| codons 1-99 PQITLWQRPLVSIKVGGQIKEALLDTGADDTVLEDIDLPGKWKPKMIGGIGGFIKVRQYD QIPIEICGKKAIGTVLVGPTPVNIIGRNMLTQLGCTLNF |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| M184V | K101E, V106M, G190A | V35T, E36A, T39E, W88C, K122E, D123S, E138A, K173T, Q174K, D177E, T200P, Q207N, R211K, F214L, V245Q, S268C, A272P, K275R, E291D, V292I, I293V, V317A | L209LV |
| >TK2024b| codons 1-324 PISPIETVPVKLKPGMDGPKVKQWPLTEEKIKALTAICEEMEKEGKISKIGPENPYNTPV FAIKKKDSTKWRKLVDFRELNKRTQDFCEVQLGIPHPAGLEKKKSMTVLDVGDAYFSVPL DESFRKYTAFTIPSINNATPGIRYQYNVLPQGWKGSPAIFQSSMTKILEPFRTKNPEIVI YQYVDDLYVASDLEIGQHRPKIEELRNHVLKWGLTTPDKKHQKEPPFLWMGYELHPDKWT VQPIQLPEKDSWTVNDIQKLVGKLNWACQIYPGIRVKQLCKLLRGTKALTDIVPLTEEAE LELAENREILKEPVHGAYYDPSKD |
References
| Author | Title | Citation |
| Non-B Workgroup | Impact of HIV-1 subtype and antiretroviral therapy on protease and reverse transcriptase genotype: Results of a global collaboration. | PLoS Med, 2005 |