Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| TK2023 | TK2023 | Denmark | 2000 | HIV1 | C | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | AZT | 104 |
| 2 | AZT+ DDI | 26 |
| 3 | AZT+ DDI+ RTV | 4 |
| 4 | AZT+ RTV+ 3TC | 8 |
| 5 | AZT+ 3TC | 8 |
| 6 | 3TC+ D4T+ IDV | 78 |
| 7 | D4T+ DDI+ NVP+ RTV+ SQV | 17 |
| 8 | D4T+ DDI+ NVP+ RTV | 52 |
| 9 | D4T+ DDI+ NVP+ RTV+ SQV | 14 |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| L10I, I15V, L19I, M36I, R41K, L63V, H69K, T74S, V75I, L89M, I93L |
| >TK2023| codons 1-99 PQITLWQRPIVTIKVGGQIKEALLDTGADDTVLEEINLPGKWKPKMIGGIGGFIKVRQYD QIVIEICGKKAIGSILVGPTPVNIIGRNMLTQLGCTLNF |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| D67N, L210LW, T215CY | K219E | Y181C | V35T, T39E, S48T, K49KR, K122E, K173I, Q174K, D177E, T200A, Q207E, H208HY, R211K, H221HY, V245Q, A272P, K277R, T286A, E291D, V292I, I293V |
| >TK2023| codons 1-324 PISPIETVPVKLKPGMDGPKVKQWPLTEEKIKALTEICEEMEKEGKITRIGPENPYNTPV FAIKKKNSTKWRKLVDFRELNKRTQDFWEVQLGIPHPAGLKKKKSVTVLDVGDAYFSVPL DEDFRKYTAFTIPSINNETPGIRYQYNVLPQGWKGSPAIFQSSMTKILEPFRIKNPEIVI CQYMDDLYVGSDLEIGQHRAKIEELREYLWKWGFCTPDEKYQKEPPFLWMGYELHPDKWT VQPIQLPEKDSWTVNDIQKLVGKLNWASQIYPGIKVRQLCKLLRGAKALTDIVPLTEEAE LELAENREILKEPVHGVYYDPSKD |
References
| Author | Title | Citation |
| Non-B Workgroup | Impact of HIV-1 subtype and antiretroviral therapy on protease and reverse transcriptase genotype: Results of a global collaboration. | PLoS Med, 2005 |