Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| TK2018 | TK2018 | Denmark | 2001 | HIV1 | C | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | AZT | 87 |
| 2 | None | 87 |
| 3 | 3TC+ AZT+ IDV | 34 |
| 4 | D4T+ DDI+ RTV | 13 |
| 5 | D4T+ DDI | 47 |
| 6 | D4T+ DDI+ NFV+ NVP | 61 |
| 7 | NFV+ NVP+ 3TC+ ABC | 110 |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| D67N, K70R, M184V, T215Y | K219E | Y181C | A98G | E28X, V35LM, T39E, S48T, K49R, K122E, D123G, I135T, K173A, D177E, V179I, T200A, I202V, Q207D, R211K, V245Q, A272P, K277R, E291D, V292I, I293V |
| >TK2018| codons 1-324 PISPIETVPVKLKPGMDGPKVKQWPLTXEKIKALLEICEEMEKEGKITRIGPENPYNTPV FAIKKKNSTRWRKLVDFRELNKRTQDFWEVQLGIPHPGGLKKKKSVTVLDVGDAYFSVPL DEGFRKYTAFTIPSTNNETPGIRYQYNVLPQGWKGSPAIFQSSMTKILEPFRAQNPEIII CQYVDDLYVGSDLEIGQHRAKVEELRDHLLKWGFYTPDEKHQKEPPFLWMGYELHPDKWT VQPIQLPEKDSWTVNDIQKLVGKLNWASQIYPGIKVRQLCKLLRGTKALTDIVPLTEEAE LELAENREILKEPVHGVYYDPSKD |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| M46MI, L90M | T12S, I13V, I15V, L19I, K20T, M36I, N37S, R41K, H69K, L89I, I93L |
| >TK2018| codons 1-99 PQITLWQRPLVSVKVGGQITEALLDTGADDTVLEEISLPGKWKPKIIGGIGGFIKVRQYD QILIEICGKKAIGTVLVGPTPVNIIGRNIMTQLGCTLNF |
References
| Author | Title | Citation |
| Non-B Workgroup | Impact of HIV-1 subtype and antiretroviral therapy on protease and reverse transcriptase genotype: Results of a global collaboration. | PLoS Med, 2005 |