Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| TK2014 | TK2014 | Denmark | 2001 | HIV1 | D | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | AZT | 4 |
| 2 | AZT+ DDC+ DDI+ SQV+ 3TC+ RTV | 52 |
| 3 | AZT+ 3TC+ RTV | 21 |
| 4 | AZT+ 3TC+ RTV+ IDV+ SQV | 8 |
| 5 | 3TC+ RTV+ D4T+ SQV | 35 |
| 6 | ABC+ DDI+ NFV+ NVP | 112 |
| 7 | DDI+ 3TC+ D4T+ EFV+ IDV+ RTV | 79 |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| M41L, L74V, V75M, M184V, L210W, T215Y | K219N | K103N, Y181C | V35T, K49R, V60I, S68G, T69TI, D121Y, K122E, I135M, S162D, D177E, I178L, V179I, Q207E, R211K, P243S, V245K, A272P, L282C, T286A, A288T, I293V, E297T | A33AP, S163SN |
| >TK2014| codons 1-324 PISPIETVPVKLKPGMDGPKVKQWPLTEEKIKPLTEICTELEKEGKISRIGPENPYNTPI FAIKKKDGIKWRKVMDFRELNKRTQDFWEVQLGIPHPAGLKKNKSVTVLDVGDAYFSVPL YEDFRKYTAFTIPSMNNETPGIRYQYNVLPQGWKGSPAIFQDNMTKILEPFRKQNPELII CQYVDDLYVGSDLEIGQHRTKIEELREHLWKWGFYTPDNKHQKEPPFLWMGYELHPDKWT VQSIKLPEKDSWTVNDIQKLVGKLNWASQIYPGIKVKQLCKCLRGAKTLTEVVPLTTEAE LELAENREILKEPVHGVYYDPSKD |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| M46L, I54V, V82A | L10V, R41K, D60E, L63P, I66IF, A71V, T74S, V77I |
| >TK2014| codons 1-99 PQITLWQRPVVTIKIGGQLKEALLDTGADDTVLEEMNLPGKWKPKLIGGIGGFVKVRQYE QIPIEFCGHKVIGSVLIGPTPANIIGRNLLTQIGCTLNF |
References
| Author | Title | Citation |
| Non-B Workgroup | Impact of HIV-1 subtype and antiretroviral therapy on protease and reverse transcriptase genotype: Results of a global collaboration. | PLoS Med, 2005 |