Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| TK2013 | TK2013a | Denmark | 2002 | HIV1 | G | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | 3TC+ AZT+ IDV | 111 |
| 2 | D4T+ RTV+ SQV | 9 |
| 3 | 3TC+ D4T+ NFV | 76 |
| 4 | ABC+ DDI+ EFV | 29 |
| 5 | DDI+ EFV+ 3TC+ D4T | 78 |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| M46I, I54V, L90M | L10I, I13V, I15V, K20I, E35D, M36I, N37D, R41K, R57K, Q61H, I66F, H69K, V82I, L89M, Q92K |
| >TK2013a| codons 1-99 PQITLWQRPIVTVKVGGQLIEALLDTGADDTVLEDIDLPGKWKPKIIGGIGGFVKVKQYD HILIEFCGKKAIGTVLVGPTPINIIGRNMMTKIGCTLNF |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| M41L, L74V, M184V, L210W, T215Y | Y188L | V179E | V21I, V35T, E36D, T39A, S48T, V60I, V106I, V118I, E169D, K173R, Q174K, D177E, T200E, Q207E, R211K, V245Q, D250E, A272PS, E291D, V292I, I293V, E297K | T240TM |
| >TK2013a| codons 1-323 PISPIETVPVKLKPGMDGPKIKQWPLTEEKIKALTDICAELEKEGKITKIGPENPYNTPI FAIKKKDSTKWRKVVDFRELNKRTQDFWEVQLGIPHPAGLKKKKSITVLDVGDAYFSIPL DKDFRKYTAFTIPSINNETPGIRYQYNVLPQGWKGSPAIFQSSMTKILDPFRRKNPEIEI YQYVDDLLVGSDLEIGQHREKIEELREHLWKWGFYTPDKKHQKEPPFLWMGYELHPDKWM VQPIQLPEKESWTVNDIQKLVGKLNWASQIYPGIKVKQLCKLLRGTKALTDIVPLTKEAE LELAENREILKEPVHGVYYDPSK |
References
| Author | Title | Citation |
| Non-B Workgroup | Impact of HIV-1 subtype and antiretroviral therapy on protease and reverse transcriptase genotype: Results of a global collaboration. | PLoS Med, 2005 |