<!--#if expr="$title" --> <!--#echo var="title" --> <!--#else --> HIV Drug Resistance Database <!--#endif -->
Stanford University HIV Drug Resistance Database - A curated public database designed to represent, store, and analyze the divergent forms of data underlying HIV drug resistance.

Isolate Data

Patient Isolate Region Year Species Subtype Source Clone Method
TK2013 TK2013 Denmark 2000 HIV1 G Plasma None

Treatment History
Order Regimen Weeks
1 3TC+ AZT+ IDV 111
2 D4T+ RTV+ SQV 9
3 3TC+ D4T+ NFV 76
4 ABC+ DDI+ EFV 29

RT Sequence
NRTIMajorDRMs NRTIMinorDRMs NNRTIMajorDRMs NNRTIMinorDRMs Polys UnusualMuts
M41L, L74V, M184V, L210W, T215Y   Y188L   V21I, V35T, T39A, S48T, K49R, V60I, V106VI, E169D, K173R, Q174K, D177E, T200E, Q207E, R211K, V245Q, D250E, A272P, E291D, V292I, I293V, E297K, D324E  
>TK2013| codons 1-324
PISPIETVPVKLKPGMDGPKIKQWPLTEEKIKALTEICAELEKEGKITRIGPENPYNTPI
FAIKKKDSTKWRKVVDFRELNKRTQDFWEVQLGIPHPAGLKKKKSITVLDVGDAYFSVPL
DKDFRKYTAFTIPSINNETPGIRYQYNVLPQGWKGSPAIFQSSMTKILDPFRRKNPEIVI
YQYVDDLLVGSDLEIGQHREKIEELREHLWKWGFYTPDKKHQKEPPFLWMGYELHPDKWT
VQPIQLPEKESWTVNDIQKLVGKLNWASQIYPGIKVKQLCKLLRGTKALTDIVPLTKEAE
LELAENREILKEPVHGVYYDPSKE

Protease Sequence
PIMajorDRMs PIMinorDRMs Polys UnusualMuts
M46I, I54V, L90M   L10I, I13V, I15V, K20I, E35D, M36I, N37D, R41K, R57K, Q61H, I66F, H69K, V82I, L89M, Q92K  
>TK2013| codons 1-99
PQITLWQRPIVTVKVGGQLIEALLDTGADDTVLEDIDLPGKWKPKIIGGIGGFVKVKQYD
HILIEFCGKKAIGTVLVGPTPINIIGRNMMTKIGCTLNF

References
Author Title Citation
Non-B Workgroup Impact of HIV-1 subtype and antiretroviral therapy on protease and reverse transcriptase genotype: Results of a global collaboration. PLoS Med, 2005