Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| TK2012 | TK2012 | Denmark | 2001 | HIV1 | A | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | 3TC+ AZT+ RTV | 3 |
| 2 | 3TC+ AZT | 21 |
| 3 | 3TC+ AZT+ IDV | 94 |
| 4 | 3TC+ D4T+ RTV+ SQV | 89 |
| 5 | None | 26 |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| I54V, L90M | L10V, I13V, K14R, I15V, K20R, E35D, M36I, R41K, R57K, I62V, H69K, T74S, L89I |
| >TK2012| codons 1-99 PQITLWQRPVVTVRVGGQLREALLDTGADDTVLEDINLPGKWKPKMIGGIGGFVKVKQYD QVLIEICGKKAIGSVLVGPTPVNIIGRNIMTQIGCTLNF |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| D67N, M184V, T215F | K219E | V35I, V60I, K122E, D123S, I135T, I142V, K173A, D177E, V179I, T200A, Q207A, R211RS, V245E, A272P, K281R, E291D, I293V, P294T |
| >TK2012| codons 1-324 PISPIETVPVKLKPGMDGPKVKQWPLTEEKIKALIEICTEMEKEGKISKIGPENPYNTPI FAIKKKNSTKWRKLVDFRELNKRTQDFWEVQLGIPHPAGLKKKKSVTVLDVGDAYFSVPL DESFRKYTAFTIPSTNNETPGVRYQYNVLPQGWKGSPAIFQSSMTKILEPFRAQNPEIII YQYVDDLYVGSDLEIGQHRAKIEELRAHLLSWGFFTPDEKHQKEPPFLWMGYELHPDKWT VQPIELPEKDSWTVNDIQKLVGKLNWASQIYPGIKVKQLCRLLRGTKALTDVVTLTEEAE LELAENREILKEPVHGVYYDPSKD |
References
| Author | Title | Citation |
| Non-B Workgroup | Impact of HIV-1 subtype and antiretroviral therapy on protease and reverse transcriptase genotype: Results of a global collaboration. | PLoS Med, 2005 |