Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| TK2010 | TK2010c | Denmark | 2003 | HIV1 | C | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | 3TC+ AZT+ IDV+ RTV | 5 |
| 2 | 3TC+ DDI+ NVP | 79 |
| 3 | D4T+ RTV+ SQV+ TDF | 7 |
| 4 | None | 2 |
| 5 | D4T+ RTV+ SQV+ TDF | 8 |
| 6 | D4T+ TDF+ LPV | 36 |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| T12TS, I15V, L19IV, M36I, R41K, Q61QE, H69K, L89M, I93L | A71AP |
| >TK2010c| codons 1-99 PQITLWQRPLVSIKVGGQIKEALLDTGADDTVLEEINLPGKWKPKMIGGIGGFIKVRQYD EILIEICGKKPIGTVLVGPTPVNIIGRNMLTQLGCTLNF |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| K20KR, K22KN, V35M, E36A, T39E, S48ST, K122E, D123G, K173Q, Q174X, D177DE, I195IL, G196GE, T200A, Q207E, R211K, V245Q, E248X, D250DE, K277R, E291D, V292I, I293V, K311KR, V317VA, D324DE | A33AP |
| >TK2010c| codons 1-333 PISPIETVPVKLKPGMDGPRVNQWPLTEEKIKPLMAICEEMEKEGKITKIGPENPYNTPV FAIKKKDSTKWRKLVDFRELNKRTQDFWEVQLGIPHPAGLKKKKSVTVLDVGDAYFSVPL DEGFRKYTAFTIPSINNETPGIRYQYNVLPQGWKGSPAIFQSSMTKILEPFRQXNPEIVI YQYMDDLYVGSDLELEQHRAKIEELREHLLKWGFTTPDKKHQKEPPFLWMGYELHPDKWT VQPIQLPXKESWTVNDIQKLVGKLNWASQIYAGIKVRQLCKLLRGTKALTDIVPLTEEAE LELAENREILREPVHGAYYDPSKELIAEIQKQG |
References
| Author | Title | Citation |
| Non-B Workgroup | Impact of HIV-1 subtype and antiretroviral therapy on protease and reverse transcriptase genotype: Results of a global collaboration. | PLoS Med, 2005 |