Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| TK2008 | TK2008 | Denmark | 2001 | HIV1 | CRF02_AG | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | 3TC+ D4T+ RTV | 2 |
| 2 | 3TC+ D4T+ IDV | 16 |
| 3 | None | 9 |
| 4 | 3TC+ D4T | 36 |
| 5 | 3TC+ D4T+ NFV | 55 |
| 6 | None | 25 |
| 7 | 3TC+ D4T+ EFV | 2 |
| 8 | 3TC+ D4T | 3 |
| 9 | 3TC+ D4T+ NVP | 36 |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| M184V | K103N | V35T, D123E, I135V, S162A, K173T, Q174K, D177E, I178M, T200A, Q207E, R211K, V245E, E248D, T286A, E291D, I293V, S322T |
| >TK2008| codons 1-324 PISPIETVPVKLKPGMDGPKVKQWPLTEEKIKALTEICTEMEKEGKISKIGPENPYNTPV FAIKKKDSTKWRKLVDFRELNKRTQDFWEVQLGIPHPAGLKKNKSVTVLDVGDAYFSVPL DKEFRKYTAFTIPSVNNETPGIRYQYNVLPQGWKGSPAIFQASMTKILEPFRTKNPEMVI YQYVDDLYVGSDLEIGQHRAKIEELREHLLKWGFTTPDKKHQKEPPFLWMGYELHPDKWT VQPIELPDKDSWTVNDIQKLVGKLNWASQIYAGIKVKQLCKLLRGAKALTDVVPLTEEAE LELAENREILKEPVHGVYYDPTKD |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| L10I, I13V, K20I, M36I, R41K, L63P, C67S, H69K, K70R, L89M |
| >TK2008| codons 1-99 PQITLWQRPIVTVKIGGQLIEALLDTGADDTVLEEINLPGKWKPKMIGGIGGFIKVRQYD QIPIEISGKRAIGTVLVGPTPVNIIGRNMLTQIGCTLNF |
References
| Author | Title | Citation |
| Non-B Workgroup | Impact of HIV-1 subtype and antiretroviral therapy on protease and reverse transcriptase genotype: Results of a global collaboration. | PLoS Med, 2005 |