Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| TK2006 | TK2006 | Denmark | 2002 | HIV1 | C | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | AZT | 7 |
| 2 | AZT+ DDI | 6 |
| 3 | DDI | 26 |
| 4 | AZT | 4 |
| 5 | AZT+ 3TC | 38 |
| 6 | AZT+ 3TC+ IDV | 33 |
| 7 | AZT+ 3TC+ RTV+ SQV | 1 |
| 8 | None | 8 |
| 9 | 3TC+ AZT | 23 |
| 10 | 3TC+ D4T+ EFV | 23 |
| 11 | None | 21 |
| 12 | 3TC+ D4T+ EFV | 112 |
| 13 | None | 6 |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| I15V, L19I, M36I, R41K, L63AV, H69K, L89M, I93L |
| >TK2006| codons 1-99 PQITLWQRPLVTIKVGGQIKEALLDTGADDTVLEEINLPGKWKPKMIGGIGGFIKVRQYD QIAIEICGKKAIGTVLVGPTPVNIIGRNMLTQLGCTLNF |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| V35T, E36A, T39D, S48T, K101R, K122E, D123G, I135IV, S162Y, K166KR, K173A, Q174K, D177E, G196M, T200A, Q207E, R211K, V245Q, D250E, A272P, K277R, E291D, I293V, V317A | L209LF |
| >TK2006| codons 1-324 PISPIETVPVKLKPGMDGPKVKQWPLTEEKIKALTAICDEMEKEGKITKIGPENPYNTPV FAIKKKDSTKWRKLVDFRELNKRTQDFWEVQLGIPHPAGLRKKKSVTVLDVGDAYFSVPL DEGFRKYTAFTIPSVNNETPGIRYQYNVLPQGWKGSPAIFQYSMTRILEPFRAKNPEIVI YQYMDDLYVGSDLEIMQHRAKIEELREHFLKWGFTTPDKKHQKEPPFLWMGYELHPDKWT VQPIQLPEKESWTVNDIQKLVGKLNWASQIYPGIKVRQLCKLLRGTKALTDVVPLTEEAE LELAENREILKEPVHGAYYDPSKD |
References
| Author | Title | Citation |
| Non-B Workgroup | Impact of HIV-1 subtype and antiretroviral therapy on protease and reverse transcriptase genotype: Results of a global collaboration. | PLoS Med, 2005 |