<!--#if expr="$title" --> <!--#echo var="title" --> <!--#else --> HIV Drug Resistance Database <!--#endif -->
Stanford University HIV Drug Resistance Database - A curated public database designed to represent, store, and analyze the divergent forms of data underlying HIV drug resistance.

Isolate Data

Patient Isolate Region Year Species Subtype Source Clone Method
TK2006 TK2006 Denmark 2002 HIV1 C Plasma None

Treatment History
Order Regimen Weeks
1 AZT 7
2 AZT+ DDI 6
3 DDI 26
4 AZT 4
5 AZT+ 3TC 38
6 AZT+ 3TC+ IDV 33
7 AZT+ 3TC+ RTV+ SQV 1
8 None 8
9 3TC+ AZT 23
10 3TC+ D4T+ EFV 23
11 None 21
12 3TC+ D4T+ EFV 112
13 None 6

Protease Sequence
PIMajorDRMs PIMinorDRMs Polys UnusualMuts
    I15V, L19I, M36I, R41K, L63AV, H69K, L89M, I93L  
>TK2006| codons 1-99
PQITLWQRPLVTIKVGGQIKEALLDTGADDTVLEEINLPGKWKPKMIGGIGGFIKVRQYD
QIAIEICGKKAIGTVLVGPTPVNIIGRNMLTQLGCTLNF

RT Sequence
NRTIMajorDRMs NRTIMinorDRMs NNRTIMajorDRMs NNRTIMinorDRMs Polys UnusualMuts
        V35T, E36A, T39D, S48T, K101R, K122E, D123G, I135IV, S162Y, K166KR, K173A, Q174K, D177E, G196M, T200A, Q207E, R211K, V245Q, D250E, A272P, K277R, E291D, I293V, V317A L209LF
>TK2006| codons 1-324
PISPIETVPVKLKPGMDGPKVKQWPLTEEKIKALTAICDEMEKEGKITKIGPENPYNTPV
FAIKKKDSTKWRKLVDFRELNKRTQDFWEVQLGIPHPAGLRKKKSVTVLDVGDAYFSVPL
DEGFRKYTAFTIPSVNNETPGIRYQYNVLPQGWKGSPAIFQYSMTRILEPFRAKNPEIVI
YQYMDDLYVGSDLEIMQHRAKIEELREHFLKWGFTTPDKKHQKEPPFLWMGYELHPDKWT
VQPIQLPEKESWTVNDIQKLVGKLNWASQIYPGIKVRQLCKLLRGTKALTDVVPLTEEAE
LELAENREILKEPVHGAYYDPSKD

References
Author Title Citation
Non-B Workgroup Impact of HIV-1 subtype and antiretroviral therapy on protease and reverse transcriptase genotype: Results of a global collaboration. PLoS Med, 2005