Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| TK2005 | TK2005b | Denmark | 2003 | HIV1 | D | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | 3TC+ D4T+ RTV | 13 |
| 2 | 3TC+ D4T+ IDV | 122 |
| 3 | 3TC+ ABC+ DDI+ EFV | 123 |
| 4 | None | 19 |
| 5 | ABC+ APV | 52 |
| 6 | AZT+ RTV+ SQV+ TDF | 26 |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| I54V, V82AT | L10LF | I13V, I15IV, K20KT, R41K, L63P, I64V, A71AV, T74S |
| >TK2005b| codons 1-99 PQITLWQRPFVTVKVGGQLTEALLDTGADDTVLEEMNLPGKWKPKMIGGIGGFVKVRQYD QIPVEICGHKVIGSVLVGPTPANIIGRNLLTQIGCTLNF |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| D67DN, T69D, K70R, L74V, T215CY | K219Q | L100I, K103N | V35T, K49R, V60I, K102E, K122KE, I135T, T139TK, I159IV, S162Y, D177E, V189VI, I202V, Q207E, R211K, L228H, V245K, D250E, A272P, K277R, L282C, L283I, T286A, A288AT, I293V, E297K | T253TN |
| >TK2005b| codons 1-334 PISPIETVPVKLKPGMDGPKVKQWPLTEEKIKALTEICTEMEKEGKISRIGPENPYNTPI FAIKKKNSDRWRKVVDFRELNKRTQDFWEVQLGIPHPAGIKENKSVTVLDVGDAYFSVPL DEDFRKYTAFTIPSTNNEKPGIRYQYNVLPQGWKGSPAVFQYSMTKILEPFRKQNPEIVI YQYMDDLYIGSDLEIGQHRTKVEELREHLLKWGFCTPDQKHQKEPPFHWMGYELHPDKWT VQPIKLPEKESWNVNDIQKLVGKLNWASQIYPGIKVRQLCKCIRGAKTLTEVVPLTKEAE LELAENREILKEPVHGVYYDPSKDLIAEIQKQGQ |
References
| Author | Title | Citation |
| Non-B Workgroup | Impact of HIV-1 subtype and antiretroviral therapy on protease and reverse transcriptase genotype: Results of a global collaboration. | PLoS Med, 2005 |