Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| TK2003 | TK2003a | Denmark | 2003 | HIV1 | CRF02_AG | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | 3TC+ AZT+ EFV | 3 |
| 2 | 3TC+ EFV+ DDI | 1 |
| 3 | 3TC+ EFV+ DDI+ ABC | 1 |
| 4 | EFV+ DDI | 57 |
| 5 | EFV+ DDI+ 3TC+ ABC+ AZT | 7 |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| L74V, M184V | L100I, K103N | E6D, V35I, V60I, S68G, T139K, S162A, K173T, Q174K, D177E, I178V, V179I, G196E, T200A, Q207E, P243T, V245Q, T286A, E291D, I293V, P294T, S322A, I326V | G316E |
| >TK2003a| codons 1-334 PISPIDTVPVKLKPGMDGPKVKQWPLTEEKIKALIEICTEMEKEGKISKIGPENPYNTPI FAIKKKDGTKWRKVVDFRELNKRTQDFWEVQLGIPHPAGIKKNKSVTVLDVGDAYFSVPL DKDFRKYTAFTIPSINNEKPGIRYQYNVLPQGWKGSPAIFQASMTKILEPFRTKNPEVII YQYVDDLYVGSDLEIEQHRAKIEELREHLLRWGFTTPDKKHQKEPPFLWMGYELHPDKWT VQTIQLPEKDSWTVNDIQKLVGKLNWASQIYAGIKVKQLCKLLRGAKALTDVVTLTEEAE LELAENREILKEPVHEVYYDPAKDLVAEIQKQGQ |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| I13V, K14R, G17E, K20I, M36I, R41K, H69K, K70R, L89M |
| >TK2003a| codons 1-99 PQITLWQRPLVTVRIGEQLIEALLDTGADDTVLEEINLPGKWKPKMIGGIGGFIKVRQYD QILIEICGKRAIGTVLVGPTPVNIIGRNMLTQIGCTLNF |
References
| Author | Title | Citation |
| Non-B Workgroup | Impact of HIV-1 subtype and antiretroviral therapy on protease and reverse transcriptase genotype: Results of a global collaboration. | PLoS Med, 2005 |