Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| CA1829 | CA4924 | U.S. | 1998 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | AZT+DDC | 41 |
| 2 | AZT+D4T+DDC | 52 |
| 3 | 3TC+D4T | 39 |
| 4 | 3TC+IDV | 32 |
| 5 | 3TC+DLV+NFV | 61 |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| M41L, T69S_VT, M184V, L210W | A62V, D67E, T215C, K219N | K103KN, Y181C | V108VI | K20R, K122E, D177E, L228H, V245E, A272P, I293V, E297K, A304G, E305X, Q334N, G335D, R356RK, A376AFSV, T386TA, A400T, S468P, L469I, L491S, A508G, Q520L |
| >CA4924| codons 1-560 PISPIETVPVKLKPGMDGPRVKQWPLTEEKIKALVEICTELEKEGKISKIGPENPYNTPV FVIKKKESSKWRKLVDFRELNKRTQDFWEVQLGIPHPAGLKKNKSVTILDVGDAYFSVPL DEDFRKYTAFTIPSINNETPGIRYQYNVLPQGWKGSPAIFQSSMTKILEPFRKQNPEIVI CQYVDDLYVGSDLEIGQHRTKIEELRQHLWRWGFCTPDNKHQKEPPFHWMGYELHPDKWT VQPIELPEKDSWTVNDIQKLVGKLNWASQIYPGIKVKQLCKLLRGTKALTEVVPLTKEAE LELGXNREILKEPVHGVYYDPSKDLIAEIQKQGNDQWTYQIYQEPFKNLKTGKYAKMRGA HTNDVKQLTEAVQKIVTESIVIWGKAPKFKLPIQKETWETWWTEYWQATWIPEWEFVNTP PLVKLWYQLEKEPIVGAETFYVDGAANRETKLGKAGYVTDRGRQKVVPITDTTNQKTELQ AIHLALQDSGSEVNIVTDSQYALGIIQGQPDKSESELVSLIIEQLIKKEKVYLAWVPAHK GIGGNEQVDKLVSAGIRKVL |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| M46I | L10F, V32T | M36I, L63P, I64V, A71V |
| >CA4923| codons 1-99 PQITLWQRPFVTIKIGGQLKEALLDTGADDTTLEEINLPGRWKPKIIGGIGGFIKVRQYD QIPVEICGHKVIGTVLVGPTPVNIIGRNLLTQIGCTLNF |
References
| Author | Title | Citation |
| Rhee, SY | HIV-1 Protease and Reverse Transcriptase Mutations: Correlations with Antiretroviral Therapy in Subtype B Isolates and Implications for Drug-Resistance Surveillance. | J Infect Dis, 2005 |