Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| TK2001 | TK2001 | Denmark | 2001 | HIV1 | D | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | 3TC+ D4T+ RTV+ SQV | 3 |
| 2 | 3TC+ D4T+ NFV | 49 |
| 3 | AZT+ DDI | 7 |
| 4 | AZT+ DDI+ SQV | 1 |
| 5 | AZT+ DDI | 8 |
| 6 | AZT+ DDI+ ABC | 28 |
| 7 | DDI+ EFV+ NFV | 13 |
| 8 | NFV+ ABC+ AZT+ NVP | 2 |
| 9 | NFV+ AZT+ NVP+ 3TC | 1 |
| 10 | NFV+ NVP+ 3TC | 25 |
| 11 | 3TC+ D4T+ EFV | 58 |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| M46I, I84V | N83D | L10I, I13V, A22V, E35G, M36I, I62V, L63P, I64V, A71V, I93L |
| >TK2001| codons 1-99 PQITLWQRPIVTVKIGGQLKEVLLDTGADDTVLEGINLPGRWKPKIIGGIGGFIKVRQYD QVPVEICGHKVIGTVLVGPTPVDVIGRNLLTQLGCTLNF |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| M41L, K70R, L74I, M184V, T215F | D67G, K219Q | L100I, Y188L | K20R, V35T, K49KR, E53Q, V60I, T69N, D123E, I135V, K166R, D177E, T200I, Q207E, R211K, D218E, V245K, D250E, A272P, K275R, K277R, Q278H, L282C, L283I, I293V, G316X |
| >TK2001| codons 1-323 PISPIETVPVKLKPGMDGPRVKQWPLTEEKIKALTEICTELEKEGKISRIGPQNPYNTPI FAIKKKGSNRWRKIVDFRELNKRTQDFWEVQLGIPHPAGIKKKKSVTVLDVGDAYFSVPL DKEFRKYTAFTIPSVNNETPGIRYQYNVLPQGWKGSPAIFQSSMTRILEPFRKQNPEIVI YQYVDDLLVGSDLEIGQHRIKIEELREHLLKWGFFTPEQKHQKEPPFLWMGYELHPDKWT VQPIKLPEKESWTVNDIQKLVGKLNWASQIYPGIRVRHLCKCIRGTKALTEVVPLTEEAE LELAENREILKEPVHXVYYDPSK |
References
| Author | Title | Citation |
| Non-B Workgroup | Impact of HIV-1 subtype and antiretroviral therapy on protease and reverse transcriptase genotype: Results of a global collaboration. | PLoS Med, 2005 |