<!--#if expr="$title" --> <!--#echo var="title" --> <!--#else --> HIV Drug Resistance Database <!--#endif -->
Stanford University HIV Drug Resistance Database - A curated public database designed to represent, store, and analyze the divergent forms of data underlying HIV drug resistance.

Isolate Data

Patient Isolate Region Year Species Subtype Source Clone Method
TK1030 TK1030a Denmark 2003 HIV1 A Plasma None

Treatment History
Order Regimen Weeks
1 3TC+ D4T+ RTV+ SQV 62
2 3TC+ D4T+ RTV+ IDV 33
3 3TC+ RTV+ IDV+ AZT+ DDI+ EFV 210

Protease Sequence
PIMajorDRMs PIMinorDRMs Polys UnusualMuts
    L10V, I13V, G16GE, E35D, M36I, R41K, R57K, L63PS, H69K, L89M  
>TK1030a| codons 1-99
PQITLWQRPVVTVKIEGQLKEALLDTGADDTVLEDINLPGKWKPKMIGGIGGFIKVKQYD
QIPIEICGKKAIGTVLVGPTPVNIIGRNMLTQIGCTLNF

RT Sequence
NRTIMajorDRMs NRTIMinorDRMs NNRTIMajorDRMs NNRTIMinorDRMs Polys UnusualMuts
M184MV   K103N   K20KR, V35T, V60I, K101KR, K122E, I135T, K173A, Q174K, D177E, V179I, T200A, I202IV, Q207A, R211X, F214FL, E248ED, D250E, T286A, K287R, E291D, V292I, I293V, E312D, D324E, I326V  
>TK1030a| codons 1-334
PISPIETVPVKLKPGMDGPRVKQWPLTEEKIKALTEICTEMEKEGKISKIGPENPYNTPI
FAIKKKDSTKWRKLVDFRELNKRTQDFWEVQLGIPHPAGLRKNKSVTVLDVGDAYFSVPL
DEDFRKYTAFTIPSTNNETPGIRYQYNVLPQGWKGSPAIFQSSMTKILEPFRAKNPEIII
YQYVDDLYVGSDLEIGQHRAKVEELRAHLLXWGLTTPDKKHQKEPPFLWMGYELHPDKWT
VQPIVLPDKESWTVNDIQKLVGKLNWASQIYAGIKVKQLCKLLRGARALTDIVPLTEEAE
LELAENREILKDPVHGVYYDPSKELVAEIQKQGQ

References
Author Title Citation
Non-B Workgroup Impact of HIV-1 subtype and antiretroviral therapy on protease and reverse transcriptase genotype: Results of a global collaboration. PLoS Med, 2005