Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| TK1027 | TK1027 | Denmark | 2002 | HIV1 | C | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | 3TC+ AZT | 4 |
| 2 | 3TC+ AZT+ IDV | 139 |
| 3 | IDV+ ABC+ EFV+ RTV | 13 |
| 4 | IDV+ ABC+ RTV+ NVP | 17 |
| 5 | None | 8 |
| 6 | ABC+ IDV+ NVP+ RTV | 47 |
| 7 | None | 4 |
| 8 | 3TC+ ABC+ AZT | 4 |
| 9 | None | 55 |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| L89V | I15V, L19I, M36I, R41K, H69K, I93IL |
| >TK1027| codons 1-99 PQITLWQRPLVTIKVGGQIKEALLDTGADDTVLEEINLPGKWKPKMIGGIGGFIKVRQYD QILIEICGKKAIGTVLVGPTPVNIIGRNVLTQLGCTLNF |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| V35T, E36A, T39AE, S48T, K122E, D123G, K173T, T200A, Q207E, R211K, V245Q, A272P, K277R, E291D, V292I, I293V |
| >TK1027| codons 1-324 PISPIETVPVKLKPGMDGPKVKQWPLTEEKIKALTAICAEMEKEGKITKIGPENPYNTPV FAIKKKDSTKWRKLVDFRELNKRTQDFWEVQLGIPHPAGLKKKKSVTVLDVGDAYFSVPL DEGFRKYTAFTIPSINNETPGIRYQYNVLPQGWKGSPAIFQSSMTKILEPFRTQNPDIVI YQYMDDLYVGSDLEIGQHRAKIEELREHLLKWGFTTPDKKHQKEPPFLWMGYELHPDKWT VQPIQLPEKDSWTVNDIQKLVGKLNWASQIYPGIKVRQLCKLLRGTKALTDIVPLTEEAE LELAENREILKEPVHGVYYDPSKD |
References
| Author | Title | Citation |
| Non-B Workgroup | Impact of HIV-1 subtype and antiretroviral therapy on protease and reverse transcriptase genotype: Results of a global collaboration. | PLoS Med, 2005 |