Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| TK1024 | TK1024 | Denmark | 2002 | HIV1 | D | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | 3TC+ AZT+ IDV | 70 |
| 2 | 3TC+ AZT+ NFV | 6 |
| 3 | 3TC+ AZT+ NFV+ IDV | 36 |
| 4 | IDV+ ABC+ D4T+ EFV+ RTV | 6 |
| 5 | IDV+ ABC+ D4T+ EFV | 23 |
| 6 | IDV+ ABC+ D4T+ EFV+ RTV | 4 |
| 7 | None | 3 |
| 8 | ABC+ D4T+ IDV+ NVP+ RTV | 6 |
| 9 | None | 8 |
| 10 | ABC+ D4T+ IDV+ NVP+ RTV | 4 |
| 11 | ABC+ D4T+ IDV+ RTV | 2 |
| 12 | None | 5 |
| 13 | ABC+ D4T+ IDV+ RTV | 76 |
| 14 | ABC+ D4T+ LPV+ NVP | 1 |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| I13V, K20M, M36I, R41K, K45KR, L63P, I64V, H69HY, I72E, P79PA |
| >TK1024| codons 1-99 PQITLWQRPLVTVKIGGQLMEALLDTGADDTVLEEINLPGKWKPRMIGGIGGFIKVRQYD QIPVEICGYKAEGTVLVGATPVNIIGRNLLTQIGCTLNF |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| V35I, K49KR, V60I, T200TI, Q207E, R211K, V245K, D250E, A272P, K275R, K277R, L282C, L283I, I293V, K311R, K323KE | Q91QH |
| >TK1024| codons 1-324 PISPIETVPVKLKPGMDGPKVKQWPLTEEKIKALIEICTEMEKEGKISRIGPENPYNTPI FAIKKKDSTKWRKLVDFRELNKRTQDFWEVHLGIPHPAGLKKKKSVTVLDVGDAYFSVPL DKDFRKYTAFTIPSINNETPGIRYQYNVLPQGWKGSPAIFQSSMTKILEPFRKQNPDIVI YQYMDDLYVGSDLEIGQHRIKIEELREHLLKWGFTTPDKKHQKEPPFLWMGYELHPDKWT VQPIKLPEKESWTVNDIQKLVGKLNWASQIYPGIRVRQLCKCIRGTKALTEVVPLTEEAE LELAENREILREPVHGVYYDPSED |
References
| Author | Title | Citation |
| Non-B Workgroup | Impact of HIV-1 subtype and antiretroviral therapy on protease and reverse transcriptase genotype: Results of a global collaboration. | PLoS Med, 2005 |