Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| TK1021 | TK1021 | Denmark | 2002 | HIV1 | C | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | 3TC+ AZT+ IDV | 52 |
| 2 | 3TC+ IDV+ D4T | 208 |
| 3 | 3TC+ IDV+ D4T+ RTV | 12 |
| 4 | ABC+ DDI+ LPV | 59 |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| K65R, M184V | V35T, E36A, T39E, S48T, V60I, S68G, V90I, K122E, D123S, I135V, E138A, K166R, K173T, E194X, T200A, Q207D, R211K, V245Q, E248D, A272P, K275KR, K277R, T286A, E291D, V292I, I293V |
| >TK1021| codons 1-311 PISPIETVPVKLKPGMDGPKVKQWPLTEEKIKALTAICEEMEKEGKITKIGPENPYNTPI FAIKRKDGTKWRKLVDFRELNKRTQDFWEIQLGIPHPAGLKKKKSVTVLDVGDAYFSVPL DESFRKYTAFTIPSVNNATPGIRYQYNVLPQGWKGSPAIFQSSMTRILEPFRTQNPDIVI YQYVDDLYVGSDLXIGQHRAKIEELRDHLLKWGFTTPDKKHQKEPPFLWMGYELHPDKWT VQPIQLPDKDSWTVNDIQKLVGKLNWASQIYPGIRVRQLCKLLRGAKALTDIVPLTEEAE LELAENREILK |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| M46I, I54V, V82A | L10F, L24I, Q58E | T12S, L19I, E35D, M36I, N37D, R41K, K55R, D60E, Q61E, I62V, L63P, H69K, L89M, I93L |
| >TK1021| codons 1-99 PQITLWQRPFVSIKIGGQIKEALIDTGADDTVLEDIDLPGKWKPKIIGGIGGFVRVREYE EVPIEICGKKAIGTVLVGPTPANIIGRNMLTQLGCTLNF |
References
| Author | Title | Citation |
| Non-B Workgroup | Impact of HIV-1 subtype and antiretroviral therapy on protease and reverse transcriptase genotype: Results of a global collaboration. | PLoS Med, 2005 |