Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| TK1020 | TK1020b | Denmark | 2004 | HIV1 | C | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | AZT | 39 |
| 2 | AZT+ DDI | 17 |
| 3 | AZT+ 3TC | 4 |
| 4 | AZT+ 3TC+ SQV | 21 |
| 5 | AZT+ 3TC+ SQV+ RTV | 147 |
| 6 | RTV+ ABC+ EFV+ IDV | 52 |
| 7 | ABC+ 3TC+ DDI+ LPV | 172 |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| M46I, I47V, I54V, V82C, L90M | L23I, K43T, F53L | L10I, I15V, L19I, K20R, E35D, M36I, N37D, R41RK, K55H, I62V, L63P, H69K, T74E, L89M, I93L |
| >TK1020b| codons 1-99 PQITLWQRPIVTIKVGGQIREAILDTGADDTVLEDIDLPGKWTPKIVGGIGGLVHVRQYD QVPIEICGKKAIGEVLVGPTPCNIIGRNMMTQLGCTLNF |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| M41L, D67N, L74V, M184V, T215Y | K103N | V35R, T39D, E44D, S48ST, K101Q, V118VI, K122E, D123G, K173T, Q174K, D177E, T200A, Q207E, L210S, R211K, D218E, V245Q, A272P, K277R, V292I, I293V, E297A |
| >TK1020b| codons 1-333 PISPIETVPVKLKPGMDGPKVKQWPLTEEKIKALREICDELEKDGKITKIGPENPYNTPV FAIKKKNSTKWRKVVDFRELNKRTQDFWEVQLGIPHPAGLQKNKSVTVLDVGDAYFSIPL DEGFRKYTAFTIPSINNETPGIRYQYNVLPQGWKGSPAIFQSSMTKILEPFRTKNPEIVI YQYVDDLYVGSDLEIGQHRAKIEELREHLSKWGFYTPEKKHQKEPPFLWMGYELHPDKWT VQPIQLPEKDSWTVNDIQKLVGKLNWASQIYPGIKVRQLCKLLRGTKALTEIVPLTAEAE LELAENREILKEPVHGVYYDPSKDLIAEIQKQG |
References
| Author | Title | Citation |
| Non-B Workgroup | Impact of HIV-1 subtype and antiretroviral therapy on protease and reverse transcriptase genotype: Results of a global collaboration. | PLoS Med, 2005 |