Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| TK1018 | TK1018 | Denmark | 2000 | HIV1 | CRF01_AE | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | AZT+ DDI | 30 |
| 2 | AZT+ DDI+ RTV | 34 |
| 3 | RTV+ 3TC+ D4T+ SQV | 113 |
| 4 | RTV+ D4T+ ABC+ EFV+ IDV | 37 |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| I84V | L33F, N83D | L10V, I13V, E34Q, M36I, N37S, R41K, L63P, H69K, L89M, I93L |
| >TK1018| codons 1-99 PQITLWQRPVVTVKIGGQLKEALLDTGADDTVFQEISLPGKWKPKMIGGIGGFIKVRQYD QIPIEICGKKAIGTVLVGPTPVDVIGRNMLTQLGCTLNF |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| D67N, T69D, K70R, M184V | K219EQ | K103N | E6D, V8I, K11T, V35T, T39K, E53D, K102KR, K122E, D123N, K173IM, Q174K, D177E, I178M, T200TA, Q207A, R211S, K238R, V245E, T286TA, E291D, I293V |
| >TK1018| codons 1-294 PISPIDTIPVTLKPGMDGPKVKQWPLTEEKIKALTEICKEMEKEGKISKIGPDNPYNTPV FAIKKKNSDRWRKLVDFRELNKRTQDFWEVQLGIPHPAGLKRNKSVTVLDVGDAYFSVPL DENFRKYTAFTIPSINNETPGIRYQYNVLPQGWKGSPAIFQSSMTKILEPFRIKNPEMVI YQYVDDLYVGSDLEIGQHRAKIEELRAHLLSWGFTTPDEKHQKEPPFLWMGYELHPDRWT VQPIELPEKDSWTVNDIQKLVGKLNWASQIYAGIKVKQLCKLLRGAKALTDVVP |
References
| Author | Title | Citation |
| Non-B Workgroup | Impact of HIV-1 subtype and antiretroviral therapy on protease and reverse transcriptase genotype: Results of a global collaboration. | PLoS Med, 2005 |