Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| TK1014 | TK1014 | Denmark | 2001 | HIV1 | D | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | AZT+ DDI+ RTV | 22 |
| 2 | AZT+ RTV+ 3TC | 21 |
| 3 | RTV+ 3TC+ D4T+ SQV | 68 |
| 4 | 3TC+ D4T+ SQV+ NFV | 18 |
| 5 | 3TC+ D4T+ NFV | 13 |
| 6 | ABC+ EFV+ IDV | 28 |
| 7 | ABC+ IDV+ D4T | 47 |
| 8 | ABC+ IDV+ D4T+ EFV | 29 |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| M46I, I84IV | L24LI | L10LV, I13V, K20I, E35D, M36I, R41K, L63P, H69K, T74S, T80TA, V82X, L89IM |
| >TK1014| codons 1-99 PQITLWQRPVVTVKIGGQLIEALIDTGADDTVLEDINLPGKWKPKIIGGIGGFIKVRQYD QIPIEICGKKAIGSVLVGPAPXNVIGRNILTQIGCTLNF |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| D67N, K70R | K219H | K103N | K238T | P14PS, V35T, T39A, K43KE, V60I, D121Y, K122E, D123E, I142IV, A158AS, D177E, I178M, T200R, E203K, Q207E, R211K, V245R, D250E, A272P, K275R, Q278H, L282C, T286A, I293V, E297EK | V118VG |
| >TK1014| codons 1-324 PISPIETVPVKLKSGMDGPKVKQWPLTEEKIKALTEICAEMEEEGKISKIGPENPYNTPI FAIKKKNSTRWRKLVDFRELNKRTQDFWEVQLGIPHPAGLKKNKSVTVLDVGDAYFSGPL YEEFRKYTAFTIPSINNETPGVRYQYNVLPQGWKGSPSIFQSSMTKILEPFRKQNPEMVI YQYMDDLYVGSDLEIGQHRRKIKELREHLLKWGFTTPDHKHQKEPPFLWMGYELHPDTWT VQPIRLPEKESWTVNDIQKLVGKLNWASQIYPGIRVKHLCKCLRGAKALTEVVPLTKEAE LELAENREILKEPVHGVYYDPSKD |
References
| Author | Title | Citation |
| Non-B Workgroup | Impact of HIV-1 subtype and antiretroviral therapy on protease and reverse transcriptase genotype: Results of a global collaboration. | PLoS Med, 2005 |