Isolate Data
Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
TK1011 | TK1011c | Denmark | 2003 | HIV1 | B | Plasma | None |
Treatment History
Order | Regimen | Weeks |
1 | 3TC+ AZT+ IDV | 1 |
2 | 3TC+ AZT | 10 |
3 | None | 17 |
4 | 3TC+ D4T+ IDV | 1 |
5 | 3TC+ D4T | 56 |
6 | None | 23 |
7 | 3TC+ AZT | 47 |
8 | ABC+ D4T+ DDI+ EFV | 20 |
9 | None | 46 |
10 | 3TC+ AZT+ RTV+ SQV | 2 |
11 | None | 1 |
12 | 3TC+ D4T+ RTV+ SQV | 103 |
Protease Sequence
PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
I13V, L19I, N37S, R41K, D60E, L63LP, I64V |
>TK1011c| codons 1-99 PQITLWQRPLVTVKIGGQIKEALLDTGADDTVLEEMSLPGKWKPKMIGGIGGFIKVRQYE QIPVEICGHKAIGTVLVGPTPVNIIGRNLLTQIGCTLNF |
RT Sequence
NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
M184V | V35T, T39IM, K49R, V60I, S68G, K101KQ, D121Y, K122E, I135T, Y144F, T165I, D177E, I178LM, T200I, Q207E, R211RK, V245Q, D250E, A272P, I274V, L282C, T286A, I293V, P294A, E297K |
>TK1011c| codons 1-311 PISPIETVPVKLKPGMDGPKVKQWPLTEEKIKALTEICIEMEKEGKISRIGPENPYNTPI FAIKKKDGTKWRKLVDFRELNKRTQDFWEVQLGIPHPAGLQKKKSVTVLDVGDAYFSVPL YEDFRKYTAFTIPSTNNETPGIRFQYNVLPQGWKGSPAIFQSSMIKILEPFRKQNPELVI YQYVDDLYVGSDLEIGQHRIKIEELREHLLKWGFTTPDKKHQKEPPFLWMGYELHPDKWT VQPIQLPEKESWTVNDIQKLVGKLNWASQIYPGVKVKQLCKCLRGAKALTEVVALTKEAE LELAENREILK |
References
Author | Title | Citation |
Non-B Workgroup | Impact of HIV-1 subtype and antiretroviral therapy on protease and reverse transcriptase genotype: Results of a global collaboration. | PLoS Med, 2005 |